Halothane and the reperfusion injury in the intact animal model

Anesthesia and Analgesia
A R Coetzee, J Moolman

Abstract

We studied the effect of halothane on regional myocardial function during acute ischemia and reperfusion in an open-chest pig model. Anesthesia was induced with thiopental and fentanyl and maintained with an intravenous (IV) infusion of pentobarbital and fentanyl. Regional myocardial function was studied with microsonometers placed in the subendocardium supplied by the left anterior descending coronary (LAD) and circumflex coronary artery (LX). Systolic function was evaluated with reference to the end-systolic pressure-length relationship (ESPLR) and regional systolic shortening. Diastolic dysfunction was studied with postsystolic shortening (PSS). Ischemia was induced with 15 min of total occlusion of the LAD artery, and thereafter reperfusion was allowed for 120 min. Five groups were studied: one group received only pentobarbital and fentanyl (n = 10); the other groups received halothane 0.2% (n = 5), 0.4% (n = 7), 0.6% (n = 5), and 0.8% (n = 5). The pentobarbital and fentanyl infusion was adjusted in the halothane groups in an effort to maintain arterial blood pressure and heart rate within specified limits (when possible). Results indicate that regional dysfunction during acute ischemia was equal among all the groups. Howev...Continue Reading

Citations

Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S ConradieJ Coetzee
May 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B A Finegan, M Cohen
Apr 24, 2001·Pharmacology & Therapeutics·R ZucchiS Ronca-Testoni
Aug 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·A CoetzeeL Macgregor

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