Halting the March: Primary Prevention of Atopic Dermatitis and Food Allergies.

The Journal of Allergy and Clinical Immunology. in Practice
Fatima BawanyKirsi M Järvinen

Abstract

Atopic dermatitis (AD) is one of the most common inflammatory skin conditions, affecting 15% to 30% of children and 2% to 10% of adults. Population-based studies suggest that having AD is associated with subsequent development of other atopic diseases, in what is known as the "atopic march." We will provide an overview of studies that investigate primary prevention strategies for the first 2 diseases in the march, namely, AD and food allergies (FA). These strategies include emollients, breastfeeding, microbial exposures, probiotics, vitamin D and UV light, water hardness, and immunotherapy. Some studies, including randomized controlled trials on emollients and microbial supplementation, have found encouraging results; however, the evidence remains limited and contradictory. With regard to breastfeeding, microbial and lifestyle exposures, vitamin D and UV light, water hardness, and immunotherapy, the lack of randomized controlled trials makes it difficult to draw definitive conclusions. Current American Academy of Pediatrics guidelines support the idea that breastfeeding for 3 to 4 months can decrease AD incidence in children less than 2 years old. Recommendations regarding a direct relationship between breastfeeding on FA, howe...Continue Reading

Citations

Aug 28, 2020·Frontiers in Pediatrics·Laura CarucciRoberto Berni Canani
Jul 9, 2020·International Journal of Molecular Sciences·Maria Maddalena SirufoMassimo De Martinis
Nov 26, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Vittoria Montecchiani, Vassilios Fanos
Jan 9, 2021·Frontiers in Pediatrics·Simona SestitoLicia Pensabene
Feb 16, 2021·Revue Française D'allergologie·G DutauA Didier
May 11, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Stanislaw J Gabryszewski, David A Hill
Jun 11, 2021·The Journal of Allergy and Clinical Immunology·Christopher H ArehartKathleen C Barnes
Oct 25, 2021·The Journal of Allergy and Clinical Immunology·Razvigor DarlenskiLuis Caraballo

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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