PMID: 3086410Jun 1, 1986

Hamster cheek pouch carcinoma: effect of incision and cortisone on growth, invasion, and metastasis

Journal of Dental Research
K TsiklakisD B Doemling

Abstract

After cheek pouch carcinomas were induced in hamsters by the application of dimethylbenzanthracene (DMBA) to the right pouch for 13 weeks, the animals were divided into four groups and observed for seven more weeks. The control group received no further treatment, two experimental groups had incisional biopsies performed on tumors in their pouches, one of these also received injections of cortisone throughout the 20-week experimental period, and a fourth group received cortisone only. The wet weights of the cancerous cheek pouches were determined, and the submandibular and parotid salivary glands with associated cervical lymph nodes, the lungs, and the liver were examined with light microscopy. The cancerous pouches of the animals that received cortisone weighed significantly less than those of animals that received no cortisone but had incisional biopsies of the tumors. There was no significant difference in the degree of histodifferentiation of the tumors among the four groups. The animals in the two groups that received cortisone had significantly more tumors that were invasive than did the animals that did not receive cortisone. Cervical lymph node metastasis occurred in 21% to 38% of the animals but was not significantly d...Continue Reading

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Citations

Oct 1, 1987·Journal of Clinical Periodontology·R L MandellS S Socransky
Jul 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·K OhtakeT Nakajima
Oct 6, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·X LiF Shinozaki
Jan 1, 1990·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J L Ebersole
Mar 10, 2020·BioMed Research International·Diana A Martínez BJaiver E Rosas Pérez

Related Concepts

Anaplasia
Biopsy
Squamous Cell Carcinoma
Cheek Structure
Adreson
Cricetus
Lymph Nodes
Lymphatic Metastasis
Mesocricetus
Buccal Mucosa

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