PMID: 6166709Apr 1, 1981Paper

Hamster female protein. A new Pentraxin structurally and functionally similar to C-reactive protein and amyloid P component

The Journal of Experimental Medicine
J E CoeJ A Sogn

Abstract

Female protein (FP), a serum protein present in normal female hamsters was found to be similar to acute-phase reactant, C-reactive protein (CRP) and serum amyloid P component (SAP) in the following ways: (a) hamster FP complexed with phosphorylcholine (PC) in a Ca++-dependent fashion as shown by its isolation from serum by affinity chromatography with PC-Sepharose and selective elution with free PC or EDTA; (b) electron microscopy of FP indicated a pentameric structure similar in size and appearance to other pentraxins; (c) the parent molecule of FP (150,000 mol wt) was composed of five noncovalantly assembled subunits of 30,000 mol wt; and (d) the amino acid analysis and terminal NH2 sequence of FP clearly showed homology with SAP-CRP. Although FP evolved from an ancestral gene common to SAP and CRP, and shares functional, morphological and structural properties with these acute-phase proteins, the biological homology of FP appears quite diverse as this protein is a prominent serum constituent (1-2 mg/ml) of normal female hamsters and under hormonal control (testosterone suppression) in males.

References

Mar 15, 1978·Biochemical and Biophysical Research Communications·D N Podell, G N Abraham
Sep 1, 1976·Ultramicroscopy·H S Slayter
May 29, 1979·Biochemistry·F T GatesT J Kindt
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J E Coe
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A P OsmandE Shelton
Apr 1, 1972·Carbohydrate Research·M HeidelbergerJ D Higginbotham
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Aug 23, 1969·British Medical Journal·K RhodesM E Monk-Jones
Feb 1, 1966·The Journal of Experimental Medicine·J HurlimannG M Hochwald
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·J E Volanakis, M H Kaplan
Apr 1, 1971·Biochemical Genetics·H C Passmore, D C Shreffler
Feb 29, 1972·Biochemistry·B Chesebro, H Metzger
Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·E C Gotschlich, G M Edelman
Jul 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·G Urbach, B Cinader
Apr 1, 1967·The Journal of Experimental Medicine·W H ChurchillH J Rapp
Dec 21, 1956·Science·O A SCHJEIDE, M R URIST
Mar 1, 1964·Biochemistry·D A YPHANTIS

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Citations

Jun 1, 1992·Protein Science : a Publication of the Protein Society·C M KinoshitaH Gewurz
Nov 1, 1991·Agents and Actions·R SchadeE Nugel
Feb 1, 1994·Molecular Neurobiology·J GhisoB Frangione
Jan 16, 2007·International Urology and Nephrology·Sahar Mohamed HamedHassan Abol-Enein
Jan 1, 1982·Journal of Immunological Methods·F C De Beer, M B Pepys
Jul 1, 1992·Molecular Immunology·L Saunero-NavaT W Du Clos
May 1, 1983·The Journal of Experimental Medicine·J E Coe, M J Ross
Apr 1, 1990·The Journal of Experimental Medicine·J E Coe, M J Ross
Jul 1, 1985·The Journal of Clinical Investigation·J E Coe, M J Ross
Oct 2, 2009·Journal of Perinatal Medicine·Laura CrucianiGian Carlo Di Renzo
May 15, 1993·European Journal of Biochemistry·G A TennentM B Pepys
Apr 1, 1990·Clinics in Dermatology·S M Breathnach, H Hintner
Jan 1, 1982·Annals of the New York Academy of Sciences·M McCarty
Jan 1, 1982·Annals of the New York Academy of Sciences·J K Anderson, J E Mole
Jan 1, 1982·Annals of the New York Academy of Sciences·I Kushner
Jan 1, 1982·Annals of the New York Academy of Sciences·M L BaltzM B Pepys
Jan 1, 1982·Annals of the New York Academy of Sciences·J E Coe
Sep 1, 1984·Scandinavian Journal of Immunology·J J Li, K P McAdam
Aug 1, 1994·Baillière's Clinical Rheumatology·E Gruys, F W Snel
Jan 19, 2006·Molecular and Biochemical Parasitology·Margaret MbuchiJohn G Raynes
Jun 4, 2016·Archives of Medical Research·Xiao-Lei HuangJing Wang
Jul 11, 2008·Seminars in Arthritis and Rheumatism·Oscar-Danilo Ortega-HernandezJuan-Manuel Anaya
Oct 23, 1997·Microscopy Research and Technique·J GilloteauxW S Hawkins
Feb 4, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Laura CrucianiSonia S Hassan
May 23, 2019·Frontiers in Immunology·Asmita Pathak, Alok Agrawal
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E CoeM J Ross
Mar 1, 1984·Scandinavian Journal of Immunology·J J LiK P McAdam
Jun 14, 2020·Autoimmunity Reviews·Qian WuHai-Feng Pan

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