PMID: 6535455Jan 1, 1984Paper

Hamster ova/human sperm penetration: correlation with count, motility, and morphology for in vitro fertilization

Archives of Andrology
R J SwansonJ McDowell

Abstract

In an analysis of 38 proven-fertile donor samples and 84 patient samples of either unproven fertility or suspected infertility, the number of hamster ova penetrated by human sperm (% HOP) was significantly different (p less than 0.05) between the donor and suspected-infertile groups. Lowest percent HOP rates; which were recorded for patients with oligozoospermia (less than 20 X 10(6) sperm per milliliter), were significantly different from donor rates (p less than 0.01). Sperm samples from 15 patients of unknown fertility were incubated with human eggs and were simultaneously incubated in the hamster ova-sperm penetration assay. All 13 patients fertilizing at least one human ovum also penetrated hamster ova at greater than 10%. The two samples failing to fertilize any human ova had one HOP above 10% and one below 10%. Interassay ranges were low over short periods of time (weeks), but the range was high (41%) for one individual when the SPA was performed months later. Fluctuations in % HOP over extended periods of time may be due to changes in male fertility status and not to unreliability of the assay.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.