Hand, foot, and mouth disease associated with coxsackievirus A10: more serious than it seems

Expert Review of Anti-infective Therapy
Lianlian BianZhenglun Liang

Abstract

Hand, foot, and mouth disease (HFMD) is a common viral childhood illness, that has been a severe public health concern worldwide, particularly in the Asia-Pacific region. According to epidemiological data of HFMD during the past decade, the most prevalent causal viruses were enterovirus (EV)-A71, coxsackievirus (CV)-A16, CV-A6, and CV-A10. The public health burden of CV-A10-related diseases has been underestimated as their incidence was lower than that of EV-A71 and CV-A16 in most HFMD outbreaks. However, cases of CV-A10 infection are more severe, and its genome is more variable, which has alerted the research community worldwide. Areas covered: In this paper, studies on the epidemiology, laboratory diagnosis, clinical manifestations, molecular epidemiology, seroepidemiology, animal models of CV-A10, and vaccines and antiviral strategies against this genotype are reviewed. In addition, the genetic evolution of circulating strains was analyzed. Expert opinion: Multivalent vaccines against EV-A71, CV-A16, CV-A6, and CV-A10 should be a next-step HFMD vaccine strategy.

References

Apr 1, 1987·The Journal of General Virology·A ItagakiT Kurimura
Jan 1, 1983·Microbiology and Immunology·A ItagakiT Kurimura
Mar 12, 2003·Journal of Medical Virology·Sushma S Nadkarni, Jagadish M Deshpande
Jan 1, 1953·British Medical Bulletin·J O TOBIN
Mar 31, 1953·Annals of the New York Academy of Sciences·G DALLDORF
Jan 1, 1955·Annual Review of Microbiology·G DALLDORF
Jun 8, 1956·Science·C F MATTERN, H G DUBUY
May 29, 2004·The Journal of General Virology·M Steven ObersteMark A Pallansch
Nov 17, 2005·Journal of Neurovirology·G Palacios, M S Oberste
Sep 8, 2009·Journal of Virological Methods·Rosemary C SheDavid W Bahler
Mar 2, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Soile BlomqvistMerja Roivainen
Jun 18, 2010·Pediatric Dermatology·Javier López DaviaIsabel Febrer Bosch
Oct 19, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yan WuVincent T K Chow
Nov 5, 2011·Journal of Medical Microbiology·V GopalkrishnaShobha D Chitambar
Dec 17, 2011·Emerging Infectious Diseases·Maria A BrachoAntonio Salazar
Jan 3, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Meghan E FuschinoKirsten St George
Mar 13, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A MirandH Peigue-Lafeuille
Jan 16, 2014·The Journal of General Virology·Alexander N LukashevChristian Drosten
Jan 17, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J LuJ Lin
Feb 14, 2014·Journal of Biomedical Science·Chee Wah TanYoke Fun Chan
Feb 20, 2014·Journal of Biomedical Science·Piyada LinsuwanonYong Poovorawan
Sep 23, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jing-Fang ChenBian-Cheng Sun
May 9, 2015·Journal of Medical Virology·Yun HuangYaqing He
May 27, 2015·Human Vaccines & Immunotherapeutics·Michel Klein, Pele Chong

❮ Previous
Next ❯

Citations

Jul 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yingzi CuiJianxun Qi
Dec 19, 2019·Human Vaccines & Immunotherapeutics·Kelei LiZhenglun Liang
Dec 16, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hong JiYu Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.