Hand-held photoacoustic imager for theranostics in 3D

IEEE Transactions on Medical Imaging
Siyu LiuYuanjin Zhenga

Abstract

A handheld approach to three-dimensional (3D) photoacoustic imaging is essential in clinical applications. To this end, we develop a 3D handheld photoacoustic imager for dynamic (temporally and spatially) volumetric visualization. In this 3D imager, the optically transmitting part and the acoustically receiving part are integrated into a single handheld probe with a compact size about 160 mm×64 mm×40 mm. Besides, a dedicated imaging reconstruction algorithm for the heterogeneous medium is developed based on the phase-shift migration (PSM) method in frequency domain, which deals well with the stratified condition in the designed system. Dynamic 3D imaging supporting flexible handheld operation is demonstrated with needle biopsy and in-vitro temperature measurement for photothermal therapy. The development of such a 3D handheld photoacoustic system paves the way for compact and handheld-operating implementations, and its further clinical exploration is promising.

Citations

Apr 3, 2020·Optics Letters·Wuyu ZhangSihua Yang
Feb 9, 2021·Advanced Science·Huangxuan ZhaoChengbo Liu
Dec 29, 2020·Physics in Medicine and Biology·Dhiman DasManojit Pramanik

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