Handedness and asymmetry of hand representation in human motor cortex

Journal of Neurophysiology
J VolkmannH Freund

Abstract

The cortical representation of five simple hand and finger movements in the human motor cortex was determined in left- and right-handed people with whole-head magnetoencephalography. Different movements were found to be represented by spatially segregated dipolar sources in primary motor cortex. The spatial arrangement of neuronal sources for digit and wrist movements was nonsomatotopic and varied greatly between subjects. As an estimator of hand area size in primary motor cortex, we determined the smallest cuboid volume enclosing the five dipole sources within the left and right hemisphere of each subject. Interhemispheric comparison revealed a significant increase of this volume in primary motor cortex opposite to the preferred hand. This asymmetry was due to a greater spatial segregation of neuronal dipole generators subserving different hand and finger actions in the dominant hemisphere. Mean Euclidean distances between dipole sources for different movements were 10.7 +/- 3.5 mm in the dominant and 9.4 +/- 3.5 mm in the nondominant hemisphere (mean +/- SD; P = 0. 01, two-tailed t-test). The expansion of hand representation in primary motor cortex could not simply be attributed to a greater number of pyramidal cells devoted ...Continue Reading

References

Sep 1, 1978·Journal of Neurophysiology·H C KwanY C Wong
Feb 1, 1992·Electroencephalography and Clinical Neurophysiology·E M WassermannL G Cohen
Jan 1, 1991·Experimental Brain Research·Z L Lü, S J Williamson
Apr 1, 1990·Brain : a Journal of Neurology·P W NathanP Deacon
Nov 1, 1970·British Journal of Psychology·M Annett
Jul 23, 1993·Science·M H Schieber, L S Hibbard
Dec 1, 1996·Current Opinion in Neurobiology·K Y Haaland, D L Harrington
Dec 1, 1996·NeuroImage·K AmuntsK Zilles

❮ Previous
Next ❯

Citations

Oct 31, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Carl Gabbard, Susan Hart
Mar 13, 2003·Human Brain Mapping·Deborah J SerrienPeter Brown
Jul 22, 2005·Experimental Brain Research·R C G HelmichA Münchau
Feb 28, 2006·Experimental Brain Research·M C Ridding, S C Flavel
Jul 22, 2006·Nature Reviews. Neuroscience·Tao Sun, Christopher A Walsh
Sep 29, 2006·The European Journal of Neuroscience·Marc Bangert, Gottfried Schlaug
May 23, 2007·Neuroreport·Todd C Handy, Christine M Tipper
Feb 9, 2007·Experimental Brain Research·T BäumerA Münchau
May 31, 2007·The Journal of Comparative Neurology·Chet C SherwoodWilliam D Hopkins
Aug 2, 2008·Journal of Neurosurgery·Srikantan NagarajanMitchel S Berger
Jul 2, 2008·Experimental Brain Research·Cori Chase, Rachael Seidler
Oct 2, 2009·Journal of Neural Engineering·J KubánekG Schalk
Aug 4, 2010·Human Brain Mapping·Dorothée V CallaertNicole Wenderoth
Jan 6, 2012·Experimental Brain Research·Diane E AdamoBernard J Martin
Dec 19, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Nisiyama, L E Ribeiro-do-Valle
Jan 15, 2015·Laterality·Yin-Ju LienHui-Chun Tsuang
Mar 12, 2015·Frontiers in Psychology·Chiara BegliominiUmberto Castiello
Sep 27, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Jee H HamYoung H Sohn
Apr 19, 2018·Frontiers in Neuroscience·Chiara BegliominiUmberto Castiello
Apr 24, 2017·Biomedical Engineering Letters·Anterpal SandhuTeresa P L Cheung
Feb 12, 2019·Journal of Parkinson's Disease·Seok Jong ChungYoung H Sohn
Apr 18, 2019·The Clinical Journal of Pain·Miguel A VallejoLaura Vallejo-Slocker
Aug 26, 2019·Brain Structure & Function·Jurgen GermannM Mallar Chakravarty
Dec 7, 2019·Experimental Brain Research·Laura PellegrinoMaura Casadio
Jun 25, 2020·Journal of Neurophysiology·S A L JayasingheR L Sainburg
Aug 29, 2020·Journal of Movement Disorders·Seok Jong ChungYoung H Sohn
May 11, 2000·Journal of Neurophysiology·R L Sainburg, D Kalakanis
Jan 17, 2004·The European Journal of Neuroscience·Roland BeisteinerLüder Deecke
May 23, 2007·Pediatric Research·Andrea GuzzettaGiovanni Cioni
Apr 10, 2009·Journal of Neurophysiology·Patrick JungRolf-Detlef Treede
Jun 25, 2010·Experimental Brain Research·John CirilloJohn G Semmler
Jul 9, 2009·Developmental Medicine and Child Neurology·Theo GasserOskar G Jenni
Jun 16, 2011·Neuroreport·Hikmat HadoushMitsuo Ochi
Nov 15, 2011·Brain Topography·Andrew C N ChenFernando L Lopes da Silva
Jan 27, 2015·Journal of Medical Systems·Walter H L PinayaJoão R Sato
Apr 25, 2018·Cerebral Cortex·Henrietta HowellsMarco Catani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Neurobiologiae Experimentalis
Malgorzata GutAnna Grabowska
Proceedings of the National Academy of Sciences of the United States of America
P DassonvilleJ Ashe
© 2022 Meta ULC. All rights reserved