Handedness, heritability, neurocognition and brain asymmetry in schizophrenia.

Brain : a Journal of Neurology
Amy Deep-SoboslayBrita Elvevåg

Abstract

Higher rates of non-right-handedness (i.e. left- and mixed-handedness) have been reported in schizophrenia and have been a centrepiece for theories of anomalous lateralization in this disorder. We investigated whether non-right-handedness is (i) more prevalent in patients as compared with unaffected siblings and healthy unrelated control participants; (ii) familial; (iii) associated with disproportionately poorer neurocognition; and (iv) associated with grey matter volume asymmetries. We examined 1445 participants (375 patients with schizophrenia, 502 unaffected siblings and 568 unrelated controls) using the Edinburgh Handedness Inventory, a battery of neuropsychological tasks and structural magnetic resonance imaging data. Patients displayed a leftward shift in Edinburgh Handedness Inventory laterality quotient scores as compared with both their unaffected siblings and unrelated controls, but this finding disappeared when sex was added to the model. Moreover, there was no evidence of increased familial risk for non-right-handedness. Non-right-handedness was not associated with disproportionate neurocognitive disadvantage or with grey matter volume asymmetries in the frontal pole, lateral occipital pole or temporal pole. Non-ri...Continue Reading

References

Nov 1, 1979·Xianggang hu li za zhi. The Hong Kong nursing journal
Feb 24, 1978·Science·A M GalaburdaN Geschwind
Jun 1, 1979·Journal of Autism and Developmental Disorders·D B HierP B Rosenberger
Nov 1, 1979·Archives of General Psychiatry·D J LuchinsR J Wyatt
May 1, 1977·Psychological Bulletin·C Hardyck, L F Petrinovich
Jul 1, 1992·Neuropsychologia·A N Gilbert, C J Wysocki
Jan 1, 1989·Neuropsychologia·P SatzM Green
Aug 1, 1989·The American Journal of Psychiatry·J Katsanis, W G Iacono
Sep 19, 1987·British Medical Journal·R M Murray, S W Lewis
May 19, 1988·Nature·D F Halpern, S Coren
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
May 1, 1981·Psychological Medicine·J H Gruzelier
Sep 1, 1980·Annals of Neurology·P B Rosenberger, D B Hier
Sep 1, 1995·Behavior Genetics·K N LalandM W Feldman
Jun 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·J J KulynychD R Weinberger
May 1, 1994·Behavior Genetics·I B Perelle, L Ehrman
Dec 1, 1994·The American Journal of Psychiatry·F X CastellanosJ L Rapoport
May 1, 1994·Journal of Abnormal Psychology·B A ClementzM Beiser
Jun 1, 1994·Schizophrenia Research·C D MissarT E Goldberg
Dec 15, 1993·Biological Psychiatry·A J BartleyD R Weinberger
Feb 12, 1999·Brain Research. Brain Research Reviews·J ShapleskeA S David
Feb 20, 1999·Archives of General Psychiatry·J S KwonM E Shenton
Mar 31, 1999·Schizophrenia Bulletin·P Satz, M F Green
Jul 13, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·R L HendrenG J Pandina
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·I SommerA Bouma
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Aug 31, 2001·Biological Psychiatry·M F EganD R Weinberger
Jun 6, 2002·Schizophrenia Research·Jacqueline J A BuijsroggeSonia Dollfus
Oct 30, 2004·Laterality·Lynn E DeLisiTimothy J Crow
May 3, 2005·Behavior Genetics·Ira B Perelle, Lee Ehrman
May 10, 2005·Acta Psychiatrica Scandinavica·M Dragovic, G Hammond
Sep 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Milan DragovicAssen Jablensky
Apr 14, 2006·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Sarah E MedlandNicholas G Martin
Dec 15, 2006·NeuroImage·Katherine L NarrArthur W Toga
Feb 20, 2007·Schizophrenia Research·Xiaobo LiLynn E DeLisi
Feb 21, 2007·Genes, Brain, and Behavior·J SavitzR Ramesar

❮ Previous
Next ❯

Citations

Sep 15, 2012·Laterality·Pablo NajtMarkus Hausmann
Feb 13, 2014·Nature Reviews. Neuroscience·Roel M WillemsClyde Francks
Apr 3, 2014·Biological Psychiatry·Aaron F Alexander-BlochNitin Gogtay
Oct 3, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Marco Hirnstein, Kenneth Hugdahl
May 8, 2015·Annals of the New York Academy of Sciences·Clyde Francks
Oct 24, 2015·Schizophrenia Research·Derek J DeanVijay A Mittal
Nov 20, 2015·Neuropsychologia·Tulya KavakliogluClyde Francks
Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Sebastian OcklenburgMarco Hirnstein
May 25, 2013·Annals of the New York Academy of Sciences·Janina Tutkuviene, Wulf Schiefenhövel
Oct 15, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Timothy J Crow
Oct 12, 2014·Parkinsonism & Related Disorders·Eeksung LeeSuk Yun Kang
Jan 18, 2011·Schizophrenia Research·Nicoletta M J van VeelenRené S Kahn
Aug 21, 2012·Psychiatry Research·Mario AltamuraAlessandro Bertolino
Nov 28, 2013·Trends in Molecular Medicine·William M Brandler, Silvia Paracchini
Dec 4, 2010·Neuropsychologia·Annick RazafimandimbySonia Dollfus
Jun 26, 2014·Schizophrenia Bulletin·Marc S LenerErin A Hazlett
Dec 9, 2017·Brain Topography·Sigita MelynyteInga Griskova-Bulanova
Apr 19, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Robert D HendersonAndrew Eisen
Jan 27, 2019·Scientific Reports·Carolien G F de KovelClyde Francks
Jun 10, 2018·Behavioral and Brain Functions : BBF·Jiacai YangYun Su
May 17, 2017·The Psychiatric Quarterly·Hui-Li Lin, Hui-Chun Tsuang
Jan 20, 2012·Deutsches Ärzteblatt International·Stefan GutwinskiFelix Bermpohl
Aug 11, 2021·European Archives of Psychiatry and Clinical Neuroscience·Jasmina MalletUNKNOWN FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group

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