Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Hong ShangDaniel B Vigneron

Abstract

Hyperpolarization of carbon-13 ((13) C) nuclei by dissolution dynamic nuclear polarization increases signal-to-noise ratio (SNR) by >10,000-fold for metabolic imaging, but care must be taken when transferring hyperpolarized (HP) samples from polarizer to MR scanner. Some (13) C substrates relax rapidly in low ambient magnetic fields. A handheld electromagnet carrier was designed and constructed to preserve polarization by maintaining a sufficient field during sample transfer. The device was constructed with a solenoidal electromagnet, powered by a nonmagnetic battery, holding the HP sample during transfer. A specially designed switch automated deactivation of the field once transfer was complete. Phantom and rat experiments were performed to compare MR signal enhancement with or without the device for HP [(13) C]urea and [1-(13) C]pyruvate. The magnetic field generated by this device was tested to be >50 G over a 6-cm central section. In phantom and rat experiments, [(13) C]urea transported via the device showed SNR improvement by a factor of 1.8-1.9 over samples transferred through the background field. A device was designed and built to provide a suitably high yet safe magnetic field to preserve hyperpolarization during sampl...Continue Reading

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Citations

Apr 30, 2017·ACS Chemical Biology·Arif WibowoDaniel M Spielman
Aug 19, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jason Graham SkinnerJan-Bernd Hövener
Apr 7, 2017·Physics in Medicine and Biology·Erin B AdamsonSean B Fain
Jun 24, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Maximilian FuettererSebastian Kozerke
Nov 13, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cornelius von MorzeMatthew E Merritt

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