PMID: 6342813Mar 1, 1983Paper

Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid

Cephalalgia : an International Journal of Headache
S KaivolaH Timonen

Abstract

Tolfenamic acid (TA), a potent inhibitor of prostaglandin (PG) biosynthesis and action, was tested prophylactically against hangover symptoms in 30 healthy volunteers in a double-blind cross-over study. One capsule of TA (200 mg) or placebo was taken before starting to drink alcohol and another before going to bed. The hangover symptoms were evaluated in the morning. TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p less than 0.001) and in reducing the reported hangover symptoms in general (p less than 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p less than 0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p less than 0.05). In a separate study with eight participants, plasma levels of PGs were followed during ingestion of alcohol with or without TA. The plasma concentrations of PGE2 and TXB2 (a metabolite of thromboxane A2) were lower in the TA group during alcohol ingestion, while PGF2 alpha and 6-keto-PGF1 alpha (a metabolite of prostacyclin) were unaffected. TXB2 correlated with blood alcohol levels in a U-shaped manner.

References

Aug 18, 1979·Lancet·H HakkarainenJ Parantainen
Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·F R George, A C Collins
Jan 1, 1979·Journal of Studies on Alcohol·M J Stuart
Jan 1, 1977·Advances in Experimental Medicine and Biology·R H Ylikahri, M O Huttunen
Jan 1, 1976·Scandinavian Journal of Rheumatology·I B LindénH Vapaatalo
Jan 1, 1976·European Journal of Pharmacology·H Karppanen, J Puurunen
Aug 10, 1974·Prostaglandins·E R Smith, M M Mason
Aug 20, 1966·British Medical Journal·T B Brewin
Feb 23, 1980·Lancet·C R StrakoschH Keen
Mar 14, 1981·Lancet·M G MarmotB J Thomas
Oct 31, 1981·British Medical Journal·O YlikorkalaL Viinikka
Jan 1, 1981·European Journal of Clinical Pharmacology·P J PentikäinenC Backman
Nov 1, 1981·Headache·V Ala-HurulaO Tokola
Jul 1, 1980·Clinical and Experimental Pharmacology & Physiology·M ThomasR Vijayakumar

Citations

Jul 12, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Kelvin K W KanJ A Rudd
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·W B PickworthJ E Henningfield
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·R L HaleK P Turner
Dec 1, 1985·Archives of Gerontology and Geriatrics·M FioravantiA Napoleoni
Nov 1, 1987·Alcohol·J D Sinclair, K Gustafsson
Dec 25, 2003·Alcohol·Dai-Jin KimJaeseung Jeong
Oct 3, 2003·European Journal of Pharmacology·Kelvin K W KanJ A Rudd
Oct 26, 2002·European Journal of Pharmacology·Kelvin K W KanJ A Rudd
Oct 1, 2008·Cephalalgia : an International Journal of Headache·M ValerianiV Guidetti
Aug 2, 2012·Advances in Preventive Medicine·Joris C Verster, O Berthélemy
Feb 16, 2007·Headache·Randolph W EvansChristine Lay
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·D F Horrobin
Jun 1, 1983·Drug and Alcohol Dependence·J Parantainen
Jan 1, 1986·The American Journal of Drug and Alcohol Abuse·R M BoginM J Young
Jan 1, 1987·The American Journal of Drug and Alcohol Abuse·R M BoginM J Young
Nov 1, 2007·The European Journal of Neuroscience·Sangsu BangSun Wook Hwang
Jul 15, 2003·The International Journal of Neuroscience·Dai-Jin KimHyo Jin Go
Mar 28, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Emily PalmerRoberta J Ward
Jul 8, 2020·Journal of Clinical Medicine·Aurora J A E van de LooJoris C Verster
Apr 5, 2020·Journal of Clinical Medicine·Joris C VersterJacqueline M Iversen
Sep 3, 2020·Neurology·David García-AzorínÁngel Luis Guerrero-Peral
May 1, 1985·Cephalalgia : an International Journal of Headache·J ParantainenE Hokkanen

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.