Hantavirus infections for the clinician: from case presentation to diagnosis and treatment

Critical Reviews in Microbiology
Maria SargianouGeorge Panos

Abstract

Hantaviruses cause Hantavirus Pulmonary Syndrome (HPS; also called Hantavirus Cardiopulmonary Syndrome) in the Americas and Hemorrhagic Fever with Renal Syndrome (HFRS) in Asia and Europe. In Scandinavia and northern Europe, a milder form of HFRS is prevalent, termed nephropathica epidemica (NE). HPS presents with acute respiratory failure, mild-moderate renal failure, thrombocytopenia, and reactive lymphocytosis. HFRS has pronounced renal dysfunction and less prominent respiratory involvement, with thrombocytopenia and hemorrhagic findings. Both syndromes have long-term sequelae. Common symptomatology is due to underlying pathophysiology, mainly increased vascular permeability and immune activation. Laboratory and imaging markers predicting disease severity are under research, allowing for more efficient patient management. Diagnosis is presumptive, based on typical clinical findings and patient history of likely rodent exposure. Confirmation of diagnosis is by serological testing and/or RT-PCR. Treatment is mainly comprised of cardiovascular, respiratory, and renal function support, with fluid and electrolyte homeostasis being crucial components of care. In HPS, the use of extracorporeal membrane oxygenation in decompensated ...Continue Reading

References

Nov 11, 1990·The Journal of Infectious Diseases·D Y QianR A Smego
Feb 15, 1989·Annals of Internal Medicine·T M Cosgriff
Sep 1, 1995·The Netherlands Journal of Medicine·M N GerdingA D Osterhaus
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·O A Alexeyev, V G Morozov
Dec 1, 1994·The British Journal of Ophthalmology·M KontkanenJ Lähdevirta
Jun 1, 1996·The Journal of Infectious Diseases·A S KhanT G Ksiazek
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B HjelleJ A Rawlings
Apr 8, 1998·Journal of the International Neuropsychological Society : JINS·R O HopkinsE D Bigler
Jul 14, 1998·Journal of Medical Virology·A PapaA Antoniadis
Aug 27, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E Y LeeK I Yoon
Nov 24, 1999·The Journal of Infectious Diseases·M TerajimaF A Ennis
Feb 26, 2000·Medical Microbiology and Immunology·R MentelB Niklasson
Jul 7, 2000·The Journal of Infectious Diseases·M BharadwajB Hjelle
Mar 20, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J SchubertB Weissbrich
May 29, 2001·Journal of Clinical Microbiology·H HujakkaO Vapalahti
May 29, 2001·Journal of Clinical Microbiology·A PapaO Vapalahti
Jan 5, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L E ChapmanUNKNOWN Ribavirin Study Group
Apr 10, 2002·Acta Neurologica Scandinavica·A-L ToivanenT Tatlisumak
Apr 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C J Peters, Ali S Khan
May 4, 2002·JAMA : the Journal of the American Medical Association·Luciana BorioUNKNOWN Working Group on Civilian Biodefense
Oct 9, 2002·Journal of Virology·Martin J RafteryGünther Schönrich
Dec 13, 2002·Journal of Virology·William E SeversonColleen B Jonsson
Sep 10, 2003·Journal of Travel Medicine·Pietro CaramelloValerio Gai
Dec 6, 1952·Journal of the American Medical Association·S KATZW H KESSLER
Oct 3, 2003·The Lancet Infectious Diseases·Olli VapalahtiAntti Vaheri
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth D KilpatrickFrancis A Ennis
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory J MertzUNKNOWN Collaborative Antiviral Study Group
Jan 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tracy RaymondErich R Mackow
May 12, 2005·Experimental & Molecular Medicine·Jin-Won SongKwangSook Park
Aug 2, 2005·Wiener klinische Wochenschrift·Emil PalTatjana Avsic-Zupanc
Sep 6, 2005·Scandinavian Journal of Infectious Diseases·Ivan PuljizNikola Makek
Dec 27, 2005·Current Molecular Medicine·Svetlana F KhaiboullinaStephen C St Jeor
Feb 21, 2006·Emerging Infectious Diseases·Valeria P MartinezPaula J Padula

❮ Previous
Next ❯

Citations

Jun 5, 2012·Antiviral Research·Anna Papa
Sep 18, 2015·Frontiers in Immunology·Sergey P MorzunovVincent C Lombardi
Apr 24, 2013·Critical Reviews in Microbiology·Dionysios Christos WatsonGeorge Panos
Feb 11, 2014·Virus Research·Luiz Tadeu Moraes FigueiredoDelia Alcira Enria
Dec 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Detlev H KrugerBoris Klempa
Aug 4, 2016·Frontiers in Microbiology·Svetlana F KhaiboullinaVincent C Lombardi
Nov 13, 2018·PLoS Neglected Tropical Diseases·Wen-Ping GuoEn-Min Zhou
Apr 16, 2020·The New England Journal of Medicine·Nicolas BarrosSarah E Turbett
Jun 3, 2020·The Journal of Infectious Diseases·Barbara KnustUNKNOWN Multistate Seoul Virus Outbreak Investigation Team
Feb 23, 2013·International Journal of Microbiology·Mark FentonAidan Coffey
Dec 7, 2019·Acta Radiologica·Olivier Lebecque, Michaël Dupont
Sep 8, 2020·Clinical and Experimental Pharmacology & Physiology·Naveed MunirAneezah Sana
Feb 23, 2020·Frontiers in Microbiology·Rongrong LiuXingan Wu
Sep 19, 2020·Journal of the Belgian Society of Radiology·Olivier LebecqueMichael Dupont
Mar 12, 2021·Bioorganic & Medicinal Chemistry Letters·Olga I YarovayaNariman F Salakhutdinov
Apr 23, 2021·International Journal of Environmental Health Research·Sima SinghPrashant Kesharwani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Maja Martinuč BergočJernej Pajek
Emerging Infectious Diseases
Yong-Zhen ZhangAlexander Plyusnin
© 2021 Meta ULC. All rights reserved