Haploidentical hematopoietic cell transplantation.

Bone Marrow Transplantation
L-P Koh, N Chao

Abstract

Haploidentical hematopoietic stem cell transplantation (HSCT) provides an opportunity for nearly all patients to benefit from HCT when a HLA genotypically matched sibling is not available. Initial results with the use of mismatched allografts led to limited enthusiasm due to GVHD and infectious complications resulting in unacceptable treatment-related morbidity and mortality. Recent advances with effective T-cell depletion, the use of 'megadoses' of stem cells, better antimicrobial therapy and reduced intensity conditioning has significantly decreased the early transplant-related mortality and GVHD. These modifications also enabled robust and prompt engraftment and led to enhancing the therapeutic benefits of haploidentical transplantation. However, the cardinal problems related to delayed immune reconstitution causing post-transplant infectious complications and relapse remain, limiting the efficacy of haploidentical transplant. Preliminary data have demonstrated the great potential in the use of adoptive cellular immunity and selective allodepletion in rapidly reconstituting immunity without GVHD. The encouraging reports from haploidentical transplant using noninherited maternal antigen (NIMA)-mismatched donors or natural kil...Continue Reading

References

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Citations

Sep 17, 2013·Bone Marrow Transplantation·A MarekUNKNOWN Swiss Blood Stem Cell Transplantation
Dec 5, 2009·Leukemia Research·Christopher C Dvorak
Sep 22, 2009·Current Opinion in Immunology·Marina Cavazzana-CalvoAlain Fischer
Oct 5, 2015·Dermatologic Clinics·Pooja VirmaniChristiane Querfeld
Mar 23, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Xiao-Jun Huang, Ying-Jun Chang
Jun 18, 2016·Advances in Hematology·Kevon Parmesar, Kavita Raj
Sep 9, 2021·The FEBS Journal·Izabella SkulimowskaKrzysztof Szade
Dec 1, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mahmoud ElsawyMohamed L Sorror

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