Haploidentical stem cell transplantation as a salvage therapy for cord blood engraftment failure in a patient with Fanconi anemia

Pediatric Blood & Cancer
Rawad RihaniMahmoud Sarhan

Abstract

A 7-year-old male with Fanconi Anemia who developed primary graft failure following one antigen-mismatched unrelated cord blood transplantation and a nonradiation-based conditioning, underwent a second hematopoietic stem cell transplantation (HSCT) from his 2-loci mismatched haploidentical father, using a nonradiation-based regimen, 79 days after the first HSCT. A sustained hematological engraftment was achieved at 9 days post-second HSCT. At 15 months post-second HSCT; the patient demonstrated normal blood counts, sustained donor chimerism, and no evidence of GVHD. Haploidentical HSCTs as primary or secondary sources of stem cells, with appropriate T-cell depletion, may be a readily available option in the absence of HLA-matched related or unrelated donors.

References

Nov 1, 1994·Leukemia Research·T YokotaA Hiraoka
Jul 1, 1993·Stem Cells·E Gluckman
Jul 25, 1998·Bone Marrow Transplantation·M RembergerJ Aschan
Jul 29, 2004·Blood·Tatsuo IchinoheUNKNOWN Japanese Collaborative Study Group for NIMA-Complementary Haploidentical Stem Cell Transplantation
Aug 19, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eliane GluckmanUNKNOWN Eurocord-Netcord and EBMT
Oct 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Joseph H ChewningFarid Boulad
Dec 18, 2007·Bone Marrow Transplantation·E Gluckman, J E Wagner
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jonas MattssonRainer Storb
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mouhab AyasHassan El-Solh

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Citations

Jan 28, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marco ZeccaFranco Locatelli
Apr 2, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Federico MoscardóGuillermo F Sanz
Dec 9, 2016·Expert Review of Hematology·Christen L EbensJohn E Wagner

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