Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine

Journal of Hematology & Oncology
Federica GiannottiArnon Nagler

Abstract

Thiotepa-busulfan-fludarabine (TBF) is a widely used conditioning regimen in single umbilical cord blood transplantation (SUCBT). More recently, it was introduced in the setting of non-T cell depleted haploidentical stem cell transplantation (NTD-Haplo). Whether TBF based conditioning provides additional benefit in transplantation from a particular alternative donor type remains to be established. This was a retrospective study based on an international European registry. We compared outcomes of de-novo acute myeloid leukemia patients in complete remission receiving NTD-Haplo (n = 186) vs. SUCBT (n = 147) following myeloablative conditioning (MAC) with TBF. Median follow-up was 23 months. Treatment groups resembled in baseline characteristics. SUCBT was associated with delayed engraftment and higher graft failure. In multivariate analysis no statistically significant differences were observed between the two groups in terms of acute or chronic graft-versus-host disease (GvHD) (HR = 1.03, p = 0.92 or HR = 1.86, p = 0.21) and relapse incidence (HR = 0.8, p = 0.65). Non-relapse mortality (NRM) was significantly higher in SUCBT as compared to NTD-Haplo (HR = 2.63, p = 0.001); moreover, SUCBT did worse in terms of overall survival (...Continue Reading

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Citations

Feb 8, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giancarlo FatobeneMary Eapen
Mar 7, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Koen W van Besien, Nina Orfali
Jul 4, 2020·Stem Cells Translational Medicine·Tamila L Kindwall-Keller, Karen K Ballen
Aug 5, 2020·Expert Review of Hematology·Mi KwonJosé Luis Díez-Martín
Jul 3, 2019·Japanese Journal of Clinical Oncology·Kittika PoonsombudlertNath Limpruttidham
Dec 26, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Federica SoraAndrea Bacigalupo
Oct 28, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jaime SanzJosé Luis Piñana
Apr 11, 2021·Cytotherapy·Ignatius M ViljoenMichael S Pepper

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Software Mentioned

NTD
R
Haplo
EUROCORD
SPSS

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