Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Qiuyin CaiWei Zheng

Abstract

Estrogens play a central role in the etiology of breast cancer. The CYP19A1 gene encodes aromatase, a key enzyme in the biosynthesis of estrogens. Several single nucleotide polymorphisms (SNP) or haplotypes in the CYP19A1 gene have been evaluated in relation to breast cancer risk. However, the results have been inconsistent. In this study, we constructed haplotypes of the CYP19A1 gene using 19 haplotype-tagging SNPs in Chinese women and evaluated the variation of this gene in relation to breast cancer risk in a population-based case-control study involving 1,140 cases and 1,244 community controls of the Shanghai Breast Cancer Study. Five common haplotypes in block 1, three common haplotypes in block 2, five common haplotypes in block 3, and four common haplotypes in block 4 were identified. No apparent association was observed between common haplotypes and breast cancer risk in analyses including all subjects nor in analyses stratified by menopausal status. Similarly, no statistically significant differences were found between cases and controls in the genotype distributions of the 19 individual SNPs and the (TTTA)(n) repeat polymorphism evaluated in the study. No overall association of breast cancer risk with common CYP19A1 ge...Continue Reading

References

Mar 25, 1998·Pharmacogenetics·V N KristensenA L Børresen-Dale
Feb 23, 1999·British Journal of Cancer·N Siegelmann-Danieli, K H Buetow
Mar 14, 2000·Oncogene·V N KristensenA L Børresen-Dale
Mar 24, 2000·Endocrine-related Cancer·N M Probst-HenschB E Henderson
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·C A HaimanD J Hunter
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·Y T GaoW Zheng
Feb 22, 2001·Carcinogenesis·S W BaxterI G Campbell
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Feb 27, 2003·Breast Cancer Research and Treatment·Christopher A HaimanCelia Byrne
Aug 29, 2003·Human Molecular Genetics·Christopher A HaimanBrian E Henderson
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Sep 28, 2006·Breast Cancer Research and Treatment·Janet E OlsonRichard M Weinshilboum
Mar 21, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Janet E OlsonCeline M Vachon

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Citations

Mar 16, 2012·Breast Cancer Research and Treatment·Roberta FerraldeschiMitch Dowsett
Apr 12, 2011·Cancer Causes & Control : CCC·Martha L SlatteryRoger K Wolff
Jan 23, 2009·Journal of Human Genetics·Kumiko KidokoroKeitaro Matsuo
Sep 6, 2008·Nature Reviews. Cancer·Linda E KelemenCeline M Vachon
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chu ChenDavid B Thomas
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronica Wendy SetiawanSara H Olson
Jul 28, 2009·Breast Cancer Research : BCR·Carolyn J CrandallJanet S Sinsheimer
Aug 1, 2008·Endocrine-related Cancer·Marc T GoodmanMichael E Carney
Jan 10, 2014·International Journal of Molecular Sciences·Karin ZinsMartin Schreiber
Jan 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shilpi ChattopadhyaySyed Akhtar Husain
Aug 7, 2014·Journal of Natural Science, Biology, and Medicine·Damineni SurekhaSatti Vishnupriya
Jan 19, 2010·Maturitas·Florence Tremollieres, Claude Ribot
May 3, 2014·Cancer Letters·Hamed Samavat, Mindy S Kurzer
Nov 11, 2005·Breast Cancer Research : BCR·Katja MetsolaAri Hirvonen
Feb 15, 2008·Breast Cancer Research : BCR·Kristjana EinarsdóttirJianjun Liu
Apr 30, 2011·The Kaohsiung Journal of Medical Sciences·Shih-Meng TsaiLi-Yu Tsai
Feb 24, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jiaoyang YinHuiwen Wang
May 27, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sumin WangZhibin Hu

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