Haplotype analysis of the polymorphic 40 Y-STR markers in Chinese populations

Forensic Science International. Genetics
Xue-Ling OuHong-Yu Sun

Abstract

Forty Y-STR loci were analyzed in 1128 males from the following six Chinese ethnic populations: Han (n=300), Hui (n=244), Korean (n=100), Mongolian (n=100), Uighur (n=284) and Tibetan (n=100), utilizing two new generation multiplex Y-STR systems, AGCU Y24 STR and GFS Y24 STR genotyping kits, which allow for the genotyping of 24 loci from a single amplification reaction in each system. The lowest estimates of genetic diversity (below 0.5) correspond to markers DYS391 (0.441658) and DYS437 (0.496977), and the greatest diversity corresponds to markers DYS385a/b (0.969919) and DYS527a/b (0.94676). A considerable number of duplicate and off-ladder alleles were also revealed. Additionally, there were 1111 different haplotypes identified from the total 1128 samples, of which 1095 were unique. Notably, no shared haplotypes between populations were observed. The estimated overall haplotype diversity (HD) was 0.999085, and its discrimination capacity (DC) was 0.970745. An MDS plot based on the genetic distances between populations showed the genetic similarity of the southern Han population to the Northern populations of Hui, Korean, Mongolian and Uighur and a clear genetic departure of the Tibetan population from other populations. For ...Continue Reading

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Citations

Dec 17, 2015·International Journal of Legal Medicine·Ying WangHong-yu Sun
May 31, 2018·International Journal of Legal Medicine·Weian DuLing Chen
Dec 13, 2016·International Journal of Legal Medicine·Hui WangWeibo Liang
Jul 23, 2018·International Journal of Legal Medicine·Jian ZhangJian Ye
Jan 17, 2017·International Journal of Legal Medicine·GuangLin HeYiPing Hou
Jan 29, 2020·Molecular Genetics & Genomic Medicine·Atif AdnanJin-Feng Xuan
Dec 7, 2018·Annals of Human Genetics·Jin-Feng XuanBao-Jie Wang
May 9, 2018·International Journal of Legal Medicine·Weian DuLing Chen
Sep 12, 2019·Forensic Sciences Research·Robert Whiting, Heather Miller Coyle
May 4, 2017·Forensic Science International. Genetics·Zheng WangYiping Hou

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