Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.

BMC Cancer
Luca CavallonePatricia N Tonin

Abstract

The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymorphisms were investigated to determine if they modify risk in BRCA mutation carriers in breast cancer cases drawn from French Canadian cancer families, a population shown to exhibit strong founder effects. The frequencies of the TP53 alleles, genotypes and haplotypes of 157 index breast cancer cases comprised of 42 BRCA1 mutation carriers, 57 BRCA2 mutation carriers, and 58 BRCA mutation-negative cases, where each case was drawn from independently ascertained families were compared. The effect of TP53 variants on the age of diagnosis was also investigated for these groups. The TP53 polymorphisms were also investigated in 112 women of French Canadian descent with no personal history of cancer. The BRCA mutation-positive groups had the highest frequency of homozygous carriers of the 72Pro allele compared with mutation-negative group. The TP53 polymorphisms exhibited linkage disequilibrium (p < 0.001), where the 72Arg and Ins16minus alleles occurred in strong disequilibrium. The highest frequency of carriers of Ins16minus-72A...Continue Reading

References

Apr 10, 1995·American Journal of Medical Genetics·M J SellerG S Tint
Feb 10, 1996·Lancet·I G CampbellV Leake
Jun 1, 1996·Carcinogenesis·A SjälanderL Beckman
Jun 1, 1997·Environmental Health Perspectives·A Weston, J H Godbold
Oct 27, 1997·American Journal of Human Genetics·S C Heath
Oct 30, 1998·American Journal of Human Genetics·P N ToninS A Narod
Jan 16, 1999·Molecular and Cellular Biology·M ThomasG Matlashewski
Apr 17, 1999·American Journal of Human Genetics·T R RebbeckM Brown
Oct 18, 2000·Molecular Cell Biology Research Communications : MCBRC·E N PapadakisD A Spandidos
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·E Levy-LahadR Gershoni-Baruch
Nov 10, 2001·Annual Review of Genomics and Human Genetics·C R Scriver
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Evgeny N SuspitsinEvgeny N Imyanitov
Feb 5, 2003·Nature Genetics·Patrick DumontMaureen Murphy
Oct 15, 2003·Genetic Epidemiology·Antonis C Antoniou, Douglas F Easton
Nov 25, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xin-En HuangKazuo Tajima
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Kathleen K OrosPatricia N Tonin
Mar 10, 2005·British Journal of Cancer·T OhayonE Friedman
May 19, 2005·International Journal of Cancer. Journal International Du Cancer·David J HughesOlga M Sinilnikova
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johanna TommiskaHeli Nevanlinna
Sep 7, 2005·Clinical Genetics·A-M LabergeG A Mitchell
Dec 21, 2005·Biochemical and Biophysical Research Communications·Alexandra M SantosRui Medeiros
Jan 19, 2006·Breast Cancer Research : BCR·Antonis C AntoniouUNKNOWN INHERIT BRCAs program members
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Amanda B SpurdleUNKNOWN Epidemiological Study of Familial Breast Cancer Study Collaborators
Feb 28, 2006·Carcinogenesis·Michael WirtenbergerBarbara Burwinkel
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sharon SimchoniEphrat Levy-Lahad
Sep 26, 2006·Oncogene·S A Narod
Nov 23, 2006·Cancer Detection and Prevention·Andrea P S DaminClaudio O P Alexandre
Jun 2, 2007·Breast Cancer Research and Treatment·Suzanna L ArcandPatricia N Tonin
Oct 11, 2011·Medical Oncology·Seda EkizogluNur Buyru

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Citations

Jul 25, 2009·Breast Cancer Research and Treatment·Zhizhong ZhangZhengdong Zhang
Aug 7, 2009·Breast Cancer Research and Treatment·Zheng HuLi Su
May 24, 2011·Breast Cancer Research and Treatment·Xiao-Feng HeK Arparkorn
May 6, 2010·Medical Oncology·Shafika AlawadiMoussa Alkhalaf
Jul 23, 2009·International Journal of Cancer. Journal International Du Cancer·Lili YanBaohui Han
Sep 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chaymaa MaroufSellama Nadifi
Jun 6, 2013·Experimental and Therapeutic Medicine·Jing HouShuting Jia
Jan 1, 2014·SpringerPlus·Meire Luzia GonçalvesAntonio Márcio Teodoro Cordeiro Silva
May 20, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giuseppe ToffoliMassimo Serra

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Methods Mentioned

BETA
genotyping

Software Mentioned

Arlequin
Statistical Product and Service Solution Package , SPSS

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