Abstract
In a hospital-based case-control study of 805 non-Hispanic whites with cutaneous melanoma and 841 cancer-free age-, sex- and ethnicity-matched control subjects, 3 VDR polymorphisms (i.e., TaqI, BsmI and FokI) were genotyped using blood samples collected between 1994 and 2006. We tested the hypothesis that the haplotypes and combined genotypes of these polymorphisms were associated with melanoma risk by interacting with known risk factors. Haplotypes t-B-F (adjusted odds ratio [OR], 0.52; 95% confidence interval [CI], 0.34-0.80) and t-B-f (adjusted OR, 0.51; CI, 0.27-0.94) were associated with a reduced risk when compared to T-b-f. The combined genotypes Tt+tt/Bb+BB/Ff+ff (adjusted OR, 0.69; CI, 0.52, 0.90) and Tt+tt/Bb+BB/FF (adjusted OR, 0.58; CI, 0.43, 0.78) were also associated with reduced risk, whereas the combined genotype TT/Bb+BB/Ff+ff genotype (adjusted OR, 2.35; CI, 1.13, 4.98) was associated with increased risk when compared to TT/bb/Ff+ff genotypes. On multivariate analysis, only the TaqI polymorphism was an independent risk factor, while the FokI polymorphism interacted with skin color (p = 0.029), moles (p = 0.017) and first-degree relatives with any cancer (p = 0.013) in modifying risk. Together, these findings s...Continue Reading
References
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N A MorrisonJ A Eisman
Dec 15, 1992·Cancer·C L Hanchette, G G Schwartz
Mar 11, 1989·Nucleic Acids Research·J H FaracoP M Frossard
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Dec 1, 1988·The Journal of Investigative Dermatology·M RansonR S Mason
Feb 9, 1985·Lancet·C GarlandO Paul
Jun 1, 1988·Archives of Dermatology·T B Fitzpatrick
Apr 1, 1993·Human Molecular Genetics·F G HustmyerM Peacock
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Jun 15, 1993·American Journal of Epidemiology·R M BostickA R Folsom
Jan 15, 1997·Journal of the National Cancer Institute·S A InglesG A Coetzee
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H AraiE Takeda
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A CroftsJ A Eisman
Feb 24, 2001·Epidemiologic Reviews·J M ZmudaR E Ferrell
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Aug 2, 2002·Breast Cancer Research and Treatment·Ming-Feng HouTsung-Jen Huang
Aug 14, 2002·The British Journal of Dermatology·J E Osborne, P E Hutchinson
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Alan C GellerHoward K Koh
Feb 20, 2003·Journal of the National Cancer Institute·Qingyi WeiMadeleine Duvic
Dec 25, 2003·American Journal of Epidemiology·Paul BrennanSimone Benhamou
Jun 4, 2004·Human Molecular Genetics·Sergey NejentsevJohn A Todd
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Markus SeifertJörg Reichrath
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Apr 30, 2005·Pharmacogenetics and Genomics·Zhensheng LiuQingyi Wei
Jun 17, 2005·Cancer Research·Esther M JohnSue A Ingles
Jul 16, 2005·Annals of Medicine·Reinhold Vieth
Aug 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wendy Y ChenSusan E Hankinson
Oct 28, 2005·American Journal of Human Genetics·Yue FangAndré G Uitterlinden
Dec 29, 2005·American Journal of Public Health·Cedric F GarlandMichael F Holick
Mar 16, 2006·Pharmacogenetics and Genomics·Chunying LiQingyi Wei
Mar 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose M Valdivielso, Elvira Fernandez
Apr 20, 2006·Carcinogenesis·Chunying LiQingyi Wei
Jul 15, 2006·The Journal of Investigative Dermatology·Li-E WangQingyi Wei
Sep 5, 2006·Carcinogenesis·Jiali HanDavid J Hunter
Sep 23, 2006·The Journal of Investigative Dermatology·Chunying LiQingyi Wei
Nov 14, 2006·BMC Cancer·Francis P Boscoe, Maria J Schymura
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chunying LiQingyi Wei
Feb 3, 2007·European Journal of Immunology·Evelyne van EttenChantal Mathieu
Citations
May 12, 2012·Archives of Dermatological Research·Annika SchäferJörg Reichrath
Feb 19, 2013·BMC Medical Genetics·Zighereda OgbahSusana Puig
Dec 25, 2008·BMC Cancer·Eva BarrosoGloria Ribas
Oct 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca Suk HeistDavid C Christiani
Jun 24, 2010·World Journal of Gastroenterology : WJG·Edmondo FalletiPierluigi Toniutto
Apr 29, 2014·Archives of Dermatological Research·Xian-Zhi ZhaoZhi-Yong Yuan
Jun 20, 2014·Human Molecular Genetics·Yi LuStuart Macgregor
Mar 26, 2013·Clinical Lung Cancer·Liwen XiongLixin Wang
May 16, 2012·Journal of the American Academy of Dermatology·Katherine A WardMaria K Hordinsky
Jul 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Li-E WangQingyi Wei
Aug 15, 2009·Cancer Epidemiology·P GapskaT Debniak
Jul 21, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Juliette A Randerson-MoorJulia A Newton Bishop
Jul 27, 2011·Bioscience Trends·Xin HuangDingzhi Fang
Nov 15, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniAlessandro Testori
Jul 24, 2014·Carcinogenesis·Patrizia GnagnarellaSara Gandini
Sep 26, 2008·Cancer·Simone Mocellin, Donato Nitti
Jun 20, 2008·Human Mutation·Chunying LiQingyi Wei
Feb 10, 2010·International Journal of Cancer. Journal International Du Cancer·Catherine M OlsenDavid C Whiteman
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Irene OrlowUNKNOWN GEM Study Group
Apr 20, 2016·Journal of Skin Cancer·Sonia KamathMyles G Cockburn
Apr 19, 2015·BMC Genetics·Wei HouJunwei Fan
Mar 5, 2013·Blood Cells, Molecules & Diseases·Syed ShafiaZafar Amin Shah
Mar 5, 2011·Molecular Oncology·Sinead Field, Julia A Newton-Bishop
May 27, 2011·Cancer Epidemiology·Rochelle Mandelcorn-MonsonMarianne Berwick
Mar 17, 2015·Mutation Research·Sara RaimondiSara Gandini
Dec 3, 2014·Cancer Letters·M C F SimõesA A C C Pais
Sep 27, 2014·BMC Cancer·Thurkaa ShanmugalingamMieke Van Hemelrijck
Oct 17, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lukasz LaczmanskiWojciech Witkiewicz
Mar 13, 2010·Melanoma Research·Tadeusz DebniakJan Lubiński
Mar 16, 2012·Scandinavian Journal of Immunology·T QidwaiM Y Khan
May 19, 2012·Expert Review of Anticancer Therapy·Paulina SzyszkaAndrzej T Slominski
Apr 5, 2019·Oncology Letters·Alina F VasiloviciRodica Cosgarea
Nov 7, 2019·Scientific Reports·Lukasz LaczmanskiFelicja Lwow
Feb 22, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Andrzej T SlominskiCraig A Elmets
Mar 11, 2020·International Journal of Molecular Sciences·Tze-An YuanFeng Liu-Smith
Dec 2, 2020·Journal of Clinical Medicine·Carolina Morgado-ÁguilaFrancisco José Rodríguez-Velasco
Jan 21, 2010·Cancer Prevention Research·Catherine M OlsenDavid C Whiteman
May 1, 2017·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ahmed Abdulahi AbdurahmanKhadijeh Mirzaei