Abstract
The National Marrow Donor Program maintains an HLA database of over 4.1 million US adult volunteers, 43,000 cord blood units, and 111,000 patients from which we identified 1,999,424 samples having allele-level HLA-A, HLA-B, or HLA-DRB1 results. We analyzed 811 rare alleles reported at a frequency of less than 1 in 50,000 in this study pool and found strong predicted haplotype associations for 90 of them. The data set includes the number of times the allele was seen, the predicted haplotypes, and the racial or ethnic groups in which it was identified. This information can be helpful in designing search strategies for patients with rare alleles requiring hematopoietic stem cell therapy.
References
Oct 19, 1985·Lancet·Z L AwdehE J Yunis
Nov 5, 1997·Transplantation·M MoriE L Milford
Dec 6, 1997·Tissue Antigens·L LinE Mignot
Sep 7, 2001·Human Immunology·K CaoM A Fernández-Viña
Jun 26, 2003·Tissue Antigens·C K HurleyM Setterholm
Oct 22, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Carolyn Katovich HurleyDennis L Confer
Jun 12, 2004·Blood·Neal FlomenbergDaniel Weisdorf
Jul 15, 2004·Blood·Effie W PetersdorfJohn A Hansen
Feb 22, 2005·Bone Marrow Transplantation·M B A HeemskerkM Oudshoorn
Citations
Dec 9, 2008·Bone Marrow Transplantation·S Meyer-MonardJ-M Tiercy
Jul 1, 2014·Transplant Immunology·Zorana GrubicRenata Zunec
Mar 14, 2013·Cytotherapy·Sen Mui TanGoetz U Grigoleit
Feb 22, 2012·Human Immunology·Sabina RendineAntonio Amoroso
Jun 2, 2009·Human Immunology·Kuo-Liang YangPy-Yu Lin
Jun 28, 2008·Human Immunology·Shu-Hui WenKuo-Liang Yang
Feb 27, 2016·International Journal of Immunogenetics·Y HeH Lv
Apr 28, 2007·Human Immunology·Pedro CanoMarcelo Fernández-Viña
Sep 12, 2007·International Journal of Immunogenetics·K L Yang, P Y Lin
Apr 3, 2008·Tissue Antigens·Z GrubićR Zunec
Mar 21, 2013·Tissue Antigens·S J MackMarcelo Fernandez-Vina
Aug 14, 2012·Tissue Antigens·Z GrubicR Zunec
Jan 18, 2011·International Journal of Immunogenetics·K L YangP Y Lin
Jun 16, 2011·Tissue Antigens·P PerrierB Proust
Jul 8, 2011·Tissue Antigens·A SchellS Tourne
Mar 4, 2010·Tissue Antigens·J H YoonE Y Roh
Jun 4, 2013·International Journal of Immunogenetics·J Y HuhM S Kang
Nov 22, 2014·Tissue Antigens·Z GrubicR Zunec
Jan 8, 2009·The Korean journal of laboratory medicine·Dong Hee WhangHye Kyung Hong
Aug 9, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jason DehnMartin Maiers
Jan 4, 2018·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Kuo-Liang Yang, Zheng-Zhong Zheng
May 4, 2007·PloS One·Caroline BessonLaurent Abel
Apr 10, 2008·Tissue Antigens·M AlcocebaR García-Sanz
Dec 29, 2018·International Journal of Immunogenetics·Nanying ChenFaming Zhu
Oct 1, 2020·International Journal of Immunogenetics·Jie ZouWang Xia Li