Haplotype associations of the MHC with psoriasis vulgaris in Chinese Hans

Clinical and Experimental Dermatology
S YangX-J Zhang

Abstract

Summary Haplotype associations of the major histocompatibility complex (MHC) with psoriasis vulgaris (PV) have been demonstrated in different racial or ethnic populations. The objective of this study was to demonstrate the different haplotype associations of the MHC in Chinese patients with psoriasis according to the type of onset and their sex. One hundred and thirty-eight patients with PV and 149 normal control subjects without psoriasis were typed for HLA-A, -B, -C, -DQA1, -DQB1 and -DRB1 by using the PCR with sequence-specific primers. The results showed: (i) HLA-A*26 (26.1% vs. 12.1%, Pc < 1 x 10(-5)), -B*27 (17.03% vs. 1.01%, Pc < 1 x 10(-7)), -Cw*0602 (15.58% vs. 5.03%, Pc < 1 x 10(-2)), -DQA1*0104 (19.93% vs. 9.40%, Pc < 1 x 10(-3)), -DQA1*0201 (22.40% vs. 10.74%, Pc < 1 x 10(-3)), -DQB1*0303 (18.12% vs. 9.73%, Pc < 1 x 10(-7)), and -DRB1*0701/02 (26.09% vs. 9.73%, Pc < 1 x 10(-7)) were significantly increased in PV patients, while HLA-B*57, -DQB1*0201 were slightly increased in PV patients. HLA-Cw*0304 (5.07% vs. 14.43%, Pc < 1 x 10(-3)), -DQA1*0501 (5.79% vs. 14.09%, Pc < 0.05) were found to be negatively associated with PV, but HLA-A*2 (2.54% vs. 6.38%, Pc < 0.5) was decreased in PV patients without statistical signi...Continue Reading

References

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C V JongeneelA Cambon-Thomsen
Aug 1, 1991·The Journal of Investigative Dermatology·A AsahinaT Juji
Sep 1, 1985·Journal of the American Academy of Dermatology·T Henseler, E Christophers
Aug 1, 1994·The British Journal of Dermatology·I IkäheimoA Tiilikainen
Jun 1, 1994·The Journal of Investigative Dermatology·G G Krueger, M Duvic
Jun 1, 1994·The Journal of Investigative Dermatology·J T ElderJ J Voorhees
Sep 1, 1996·The British Journal of Dermatology·H F GonzagaM Gerbase-Delima
Nov 5, 1997·The Journal of Investigative Dermatology·C EnerbäckG Swanbeck
Sep 15, 1998·Human Molecular Genetics·J Bhalerao, A M Bowcock
Mar 3, 1999·American Journal of Human Genetics·R O Leder, S E Hodge
May 10, 2000·American Journal of Human Genetics·R P NairJ T Elder
Sep 26, 2000·Molecular Genetics and Metabolism·F CaponG Novelli
Nov 16, 2001·Archives of Dermatology·J T ElderJ J Voorhees
May 2, 2002·The Journal of Investigative Dermatology·Francesca CaponRichard Trembath
Jul 9, 2002·International Journal of Dermatology·Charoen ChoonhakarnChanvit Leelayuwat
Oct 23, 2002·International Journal of Dermatology·Xuejun ZhangShanyu Chen

❮ Previous
Next ❯

Citations

Jan 8, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shu-Mei HeJian-Jun Zhang
Nov 21, 2007·Clinics in Dermatology·Johann E Gudjonsson, James T Elder
Apr 26, 2006·The British Journal of Dermatology·L FryD J Unsworth
Feb 21, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·F F CassiaL C S Porto
Aug 16, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·Y JinX Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.