Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations

Stem Cells and Development
Anna ZimmermannJean Villard

Abstract

High expectations surround the area of stem cells therapeutics. However, the cells' source-adult or embryonic-and the cells' origin-patient-derived autologous or healthy donor genetically unrelated-remain subjects of debate. Autologous origins have the advantage of a theoretical absence of immune rejection by the recipient. However, this approach has several limitations with regard to the disease of the recipient and to potential problems with the generation, expansion, and manipulation of autologous induced pluripotent stem cells (iPS cells) preparation. An alternative to using autologous cells is the establishment of a bank of well-characterized adult cells that would be used to generate iPS cells and their derivatives. In the context of transplantation, such cells would come from genetically unrelated donors and the immune system of the recipient would reject the graft without immunosuppressive therapy. To minimize the risk of rejection, human leukocyte antigen (HLA) compatibility is certainly the best option, and the establishment of an HLA-organized bank would mean having a limited number of stem cells that would be sufficient for a large number of recipients. The concept of haplobanking with HLA homozygous cell lines woul...Continue Reading

References

Jul 1, 1993·Human Immunology·D D KostyuC Ober
Mar 31, 1999·Immunology Today·D S Gould, H Auchincloss
Nov 5, 2002·Nature Reviews. Immunology·J Andrew BradleyRoger A Pedersen
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·Rebecca H Buckley
Mar 24, 2004·Trends in Biotechnology·Micha Drukker, Nissim Benvenisty
Jul 28, 2004·Stem Cells·Li LiMickie Bhatia
Dec 8, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Yoel Shufaro, Benjamin E Reubinoff
Jun 25, 2005·Chemistry & Biology·Alice A McCarthy
Mar 1, 2006·Lancet·Mahendra S Rao, Jonathan M Auerbach
May 24, 2006·FEBS Letters·Heli SkottmanOuti Hovatta
Dec 16, 2006·Science·Kitai KimGeorge Q Daley
Mar 17, 2007·The American Journal of Bioethics : AJOB·Kayhan Parsi, Mark G Kuczewski
May 15, 2007·The American Journal of Bioethics : AJOB·Jason T Eberl
Jun 28, 2007·Cloning and Stem Cells·E S RevazovaM V Pryzhkova
Aug 22, 2007·Current Opinion in Immunology·Paul J FairchildHerman Waldmann
Aug 22, 2007·The American Journal of Bioethics : AJOB·Jason P Lott, Julian Savulescu
Aug 22, 2007·The American Journal of Bioethics : AJOB·Delia Outomuro
Aug 22, 2007·The American Journal of Bioethics : AJOB·Jonathan Kimmelman
Dec 21, 2007·Cloning and Stem Cells·E S RevazovaJ D Janus
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nathan J RobertsonPaul J Fairchild
Dec 22, 2007·The American Journal of Bioethics : AJOB·John C Moskop
Jan 25, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Denise M OlianskyTheresa Hahn
Apr 10, 2008·Cell Stem Cell·P Pearl O'RourkeKate Gallin Heffernan
Jul 10, 2008·Nature Biotechnology·Norio NakatsujiKatsushi Tokunaga
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rutger-Jan SwijnenburgJoseph C Wu
Mar 27, 2009·Journal of Cellular and Molecular Medicine·Olivier Preynat-SeauveJean Villard
Jul 10, 2009·Stem Cell Research·Rosario M Isasi, Bartha M Knoppers
Oct 3, 2009·British Journal of Haematology·Sergio QuerolJose Alejandro Madrigal
Oct 23, 2009·Tissue Antigens·W KlitzC K Hurley
Feb 18, 2010·Blood·Avital L AmirMirjam H M Heemskerk
Mar 26, 2010·Stem Cell Reviews and Reports·Ying WangJames Adjaye
Apr 2, 2010·Tissue Antigens·S G E MarshJ Trowsdale
Apr 7, 2010·Ageing Research Reviews·Meirong LiXiaobing Fu
Jun 18, 2010·Journal of Dental Research·N TamaokiK Tezuka
Oct 5, 2010·Cell Transplantation·Shih-Ping LiuShinn-Zong Lin

❮ Previous
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Citations

Jan 11, 2014·Stem Cell Research & Therapy·Jean-Sébastien HulotRoger J Hajjar
May 13, 2014·Blood Cancer Journal·D FocosiM Pistello
Aug 16, 2014·Journal of Immunology Research·Casimir de Rham, Jean Villard
May 30, 2013·Development·Conor M RamsdenPeter J Coffey
Jan 23, 2016·Trends in Molecular Medicine·Marco Zarbin
Dec 15, 2015·Advanced Drug Delivery Reviews·Henning KempfRobert Zweigerdt
Sep 19, 2015·Critical Reviews in Oncology/hematology·Stijn Vanhee, Bart Vandekerckhove
Oct 15, 2014·Biotechnology and Bioengineering·Alaina C SchlinkerWilliam M Miller
Sep 18, 2014·The Korean Journal of Internal Medicine·Sebastian DieckeJi Hyeon Ju
May 2, 2015·Regenerative Medicine·Eleanor M Bolton, John Andrew Bradley
Oct 17, 2015·PloS One·Silvina Epsztejn-LitmanRachel Eiges
Jun 2, 2016·Journal of Neurochemistry·Katrin I AndreassonLinda J Van Eldik
Feb 28, 2015·Stem Cells Translational Medicine·Melissa K Carpenter, Mahendra S Rao
Sep 16, 2017·Pediatric Research·Kimihiko Banno, Mervin C Yoder
Dec 24, 2017·Stem Cells Translational Medicine·Yasuo MorishimaUNKNOWN Japanese Cord Blood Transplantation Histocompatibility Research Group
Nov 21, 2017·Current Molecular Biology Reports·Sujoy BhattacharyaEdward Chaum
Dec 17, 2020·Frontiers in Bioengineering and Biotechnology·Suman C NathDerrick E Rancourt
Feb 15, 2020·Molecular Therapy. Methods & Clinical Development·Vera J MehlerMelanie L Moore

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