Jun 9, 2016

Haplotype block dynamics in hybrid populations

BioRxiv : the Preprint Server for Biology
Thijs JanzenArne Traulsen


When species originate through hybridization, the genomes of the ancestral species are blended together. Over time genomic blocks that originate from either one of the ancestral species accumulate in the hybrid genome through genetic recombination. Modeling the accumulation of ancestry blocks can elucidate processes and patterns of genomic admixture. However, previous models have ignored ancestry block dynamics for chromosomes that consist of a discrete, finite number of chromosomal elements. Here we present an analytical treatment of the dynamics of the mean number of blocks over time, for continuous and discrete chromosomes, in finite and infinite populations. We describe the mean number of haplotype blocks as a universal function dependent on population size, the number of genomic elements per chromosome, the number of recombination events, and the initial relative frequency of the ancestral species.

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Mentioned in this Paper

Nucleic Acid Hybridization Procedure
Recombination, Genetic
Genomic DNA
Population Group

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