Haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring

Genetic Epidemiology
M A Van der Meulen, G te Meerman

Abstract

In diseases with a complex mode of inheritance, families with multiple affected individuals are difficult to ascertain. The haplotype sharing statistic (HSS) uses (hidden) co-ancestry between affected individuals from a founder population. These affected individuals will likely not only share the same mutation(s), but also the surrounding haplotype. We show that this method gives a low false positive rate, but does not detect genes in the nuclear families of Problem 2A of the GAW data. We also give evidence based on simulations and empirical studies in real population based data that the HSS method has statistical power.

References

Nov 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G J Te MeermanL A Sandkuijl

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Citations

Feb 18, 2005·Nature Reviews. Genetics·Joel N Hirschhorn, Mark J Daly
Apr 14, 2012·Annals of Human Genetics·Wan-Yu LinNianjun Liu
Apr 20, 2005·Human Heredity·L BeckmannJ Chang-Claude
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Jan 17, 2002·Genetic Epidemiology·D Qian, D C Thomas

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