Haplotype specific alteration of diabetes MHC risk by olfactory receptor gene polymorphism

Autoimmunity Reviews
Mohamed M Jahromi

Abstract

Evidence for genes associated with risk for Type 1 diabetes (T1D) in the extended region of the major histocompatibility complex (MHC) genes is accumulating. The aim of this study was to investigate the association pattern of the extended MHC region with T1D susceptibility to identify effects independent of well established DR/DQ genes. A total of 394 Europid families with T1D were genotyped for the single nucleotide polymorphism (SNP) in the olfactory receptor family 14, subfamily J, member 1 (OR14J1) gene, rs9257691, in the MHC telomeric region. The OR provides "an internal depiction of our external world" through the capture of odorant molecules in the main OR system by several large families of G-protein coupled receptors (GPCR). These receptors transduce and chemosignals into the central nervous system (CNS). This SNP was chosen to identify its association with T1D. Interestingly, OR14J1C allele was significantly associated with T1D that seems to go with DRB1*0401, Χ(2)=10.9, p=0.0003. However, by fixing both genes of DR*0401-DQB1*0302, high risk, the association of T1D with OR14J1C still existed, Χ(2)=7.4, p=0.005. The occurrence of association of the OR14J1C allele with T1D patients with DRB1*401/DQB1*0302 is an independ...Continue Reading

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Citations

Dec 13, 2012·Clinical Reviews in Allergy & Immunology·Carlo PerriconeYehuda Shoenfeld
May 24, 2015·Autoimmunity Reviews·Kostas KakleasKyriaki Karavanaki
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Gianni BelcaroMark Dugall
Aug 20, 2021·British Journal of Pharmacology·Siyu ZhangHanbing Li

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