Haplotype test reveals departure from neutrality in a segment of the white gene of Drosophila melanogaster.

Genetics
D A Kirby, Wolfgang Stephan

Abstract

Restriction map studies previously revealed extensive linkage disequilibria in the transcriptional unit of the white locus in natural Drosophila melanogaster populations. To understand the causes of these disequilibria, we sequenced a 4722-bp region of the white gene from 15 lines of D. melanogaster and 1 line of Drosophila simulans. Statistical tests applied to the entire 4722-bp region do not reject neutrality. In contrast, a test for high-frequency haplotypes ("Haplotype test") revealed an 834-bp segment, encompassing the 3' end of intron 1 to the 3' end of intron 2, in which the structure of variation deviates significantly from the predictions of a neutral equilibrium model. The variants in this 834-bp segment segregate as single haplotype blocks. We proposed that these unusually large haplotype blocks are due to positive selection on polymorphisms within the white gene, including a replacement polymorphism, Arg-->Leu, within this segment.

Citations

Feb 24, 2006·PLoS Biology·Benjamin F VoightJonathan K Pritchard
Dec 12, 2007·Molecular Biology and Evolution·Nicolas DeromeCatherine Montchamp-Moreau
Oct 24, 2003·Genetics·Humberto QuesadaMontserrat Aguadé
May 23, 2002·Genetics·Josep M Comeron, Martin Kreitman
Mar 12, 2004·Molecular Biology and Evolution·Emmanuelle BaudryMichel Veuille
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Alberto G SáezFrancisco J Ayala
Nov 10, 2001·Annual Review of Genomics and Human Genetics·M Kreitman
May 11, 1999·Trends in Ecology & Evolution·J Hey
Jul 30, 2002·Molecular Ecology·Michael J Ford
Sep 25, 2003·Genetics·Christopher ToomajianMartin Kreitman

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