Haplotype variation at the IBD5/SLC22A4 locus (5q31) in coeliac disease in the Irish population

Tissue Antigens
A W RyanR McManus

Abstract

In addition to the well-established association of coeliac disease (CD) with HLA-DQ (6p21) and possibly CTLA4 (2q33), there is considerable evidence for a susceptibility locus on chromosome 5q, which contains many potential candidates for inflammatory disease, including a cluster of cytokine genes in 5q31. CD cases and controls were genotyped for four single-nucleotide polymorphism (SNP) markers that together characterize >90% of the haplotype variation at the IBD5 locus encoding, among others, the SLC22A4 gene. IBD5 and SLC22A4 map to 5q31 and have recently been associated with Crohn's disease and rheumatoid arthritis. Haplotype frequencies do not differ significantly between CD cases and controls in the Irish population, and therefore the chromosome 5 CD susceptibility locus most likely lies elsewhere on 5q.

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Citations

Jun 1, 2005·Best Practice & Research. Clinical Gastroenterology·David A van HeelCisca Wijmenga
Aug 30, 2007·European Journal of Human Genetics : EJHG·Asa Torinsson NaluaiJan Wahlström
Aug 2, 2007·Journal of Pediatric Gastroenterology and Nutrition·Anna LatianoVito Annese
Mar 23, 2019·Expert Review of Gastroenterology & Hepatology·Marjorie M WalkerSimon Keely
Nov 3, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John Nerbonne
Feb 16, 2005·Current Opinion in Gastroenterology·G Robins, P D Howdle

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