Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women.

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Jessica K PaulusDavid C Christiani

Abstract

Epidemiologic and biologic evidence suggests that lung cancer has different clinical and biological characteristics in women, and that estrogen may contribute to the pathogenesis of non-small cell lung cancer (NSCLC). We investigated whether germline variation in the estrogen receptor-beta gene (ESR2) is associated with lung cancer risk among 1021 female cases and 826 female controls enrolled in the Lung Cancer Susceptibility Study at the Massachusetts General Hospital from 1992 to 2004. Four haplotype-tagging polymorphisms (htSNPs) (rs3020450, rs1256031, rs1256049, rs4986938) captured the common genetic variation across the ESR2 locus from a set of markers culled from healthy controls from a public database and sequencing the coding regions of 95 breast cancer cases. Using the expectation-maximization algorithm, five common haplotypes were resolved (CCGC (43%), TCAT (287%), TCAC (11%), CCAC (9%) and CCAT (6%)). Multivariate logistic regression was used to estimate adjusted odds ratios (OR) and their 95% confidence intervals (95% CI) for individual htSNPs and haplotype scores. Neither the four individual htSNPs nor their resolved haplotypes were associated with lung cancer risk in the entire population, nor in strata defined by...Continue Reading

References

Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·H O AdamiL Bergkvist
Jun 1, 1994·Journal of the National Cancer Institute·E Taioli, E L Wynder
Aug 1, 1993·International Journal of Epidemiology·R E HarrisE L Wynder
Apr 22, 1993·International Journal of Cancer. Journal International Du Cancer·K E OsannT Taylor
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Jul 29, 1996·International Journal of Cancer. Journal International Du Cancer·U KaiserK Havemann
Sep 15, 1996·American Journal of Epidemiology·A G SchwartzG M Swanson
Nov 15, 1997·Journal of the National Cancer Institute·M J ThunC W Heath
Mar 1, 2000·American Journal of Epidemiology·L N KolonelF S Nagamine
Jun 26, 2001·Environmental and Molecular Mutagenesis·Y W ChengH Lee
Mar 26, 2002·Molecular and Cellular Endocrinology·Michael J FascoSimon D Spivack
Jul 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Steen MollerupAage Haugen
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E RadzikowskaK Roszkowski
Dec 5, 2002·Pharmacoepidemiology and Drug Safety·Janine A BlackmanSamuel Shapiro
Mar 20, 2003·Journal of the National Cancer Institute·Peter B BachColin B Begg
Apr 26, 2003·International Journal of Epidemiology·Michaela KreuzerH-Erich Wichmann
Sep 23, 2003·Epidemiology·David P MillerDavid C Christiani
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew B SchabathMargaret R Spitz
Jun 3, 2004·Journal of the National Cancer Institute·Chris BainGraham A Colditz
Jun 2, 2005·International Journal of Cancer. Journal International Du Cancer·Ying LiuShoichiro Tsugane
Oct 11, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sally W ThurstonDavid C Christiani
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ann G SchwartzSam Brooks
Dec 13, 2005·Nature Reviews. Cancer·D J HunterUNKNOWN National Cancer Institute Breast and Prostate Cancer Cohort Consortium
Aug 25, 2006·American Journal of Epidemiology·Hazel B NicholsPolly A Newcomb
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yen-Ching ChenStephanie J Weinstein
Oct 16, 2007·International Journal of Cancer. Journal International Du Cancer·UNKNOWN Breast and Prostate Cancer Cohort ConsortiumMeredith Yeager
Dec 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann G SchwartzFulvio Lonardo
Mar 20, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carmen RodriguezEugenia E Calle
Feb 4, 2010·American Journal of Epidemiology·Jessica K PaulusDavid C Christiani

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Citations

Aug 25, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kuan-Yu ChenUNKNOWN GELAC Study Group
Nov 13, 2013·Seminars in Thoracic and Cardiovascular Surgery·Crystal M North, David C Christiani
Apr 3, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sébastien CouraudPierre-Jean Souquet
Oct 14, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xi-Ying WangHong-Chun Liu
Dec 10, 2014·Biochemical and Biophysical Research Communications·Jen-Chung KoYun-Wei Lin

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