Abstract
Minor histocompatibility (H) antigens are targets of graft-vs-host disease and graft-vs-tumor responses after human leukocyte antigen matched allogeneic hematopoietic stem cell transplantation. Recently, we reported a strategy for genetic mapping of linkage disequilibrium blocks that encoded novel minor H antigens using the large dataset from the International HapMap Project combined with conventional immunologic assays to assess recognition of HapMap B-lymphoid cell line by minor H antigen-specific T cells. In this study, we have constructed and provide an online interactive program and demonstrate its utility for searching for single-nucleotide polymorphisms (SNPs) responsible for minor H antigen generation. The website is available as 'HapMap SNP Scanner', and can incorporate T-cell recognition and other data with genotyping datasets from CEU, JPT, CHB, and YRI to provide a list of candidate SNPs that correlate with observed phenotypes. This method should substantially facilitate discovery of novel SNPs responsible for minor H antigens and be applicable for assaying of other specific cell phenotypes (e.g. drug sensitivity) to identify individuals who may benefit from SNP-based customized therapies.
References
Mar 7, 1998·Science·J M den HaanE Goulmy
Jan 20, 1999·The Journal of Experimental Medicine·H DolstraE van de Wiel-van Kemenade
Dec 22, 1999·Immunogenetics·H RammenseeS Stevanović
Jan 10, 2001·The Journal of Experimental Medicine·A G BricknerS R Riddell
Nov 26, 2002·Tissue Antigens·Y AkatsukaJ A Hansen
May 29, 2003·The Journal of Experimental Medicine·Yoshiki AkatsukaToshitada Takahashi
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
May 4, 2004·Nature Reviews. Cancer·Marie Bleakley, Stanley R Riddell
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Dec 3, 2005·The Journal of Clinical Investigation·Eric Spierings, Els Goulmy
Dec 3, 2005·The Journal of Clinical Investigation·Björn de RijkeHarry Dolstra
Apr 6, 2007·Blood·Takakazu KawaseToshitada Takahashi
Jun 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·R Stephanie HuangM Eileen Dolan
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Jan 8, 2008·Blood·Takakazu KawaseYoshiki Akatsuka
May 9, 2008·Drug Metabolism Reviews·Daniel W NebertElliot S Vesell
Sep 24, 2008·Blood·Michi KameiYoshiki Akatsuka
Nov 13, 2008·The Journal of Experimental Medicine·Robbert M SpaapenTuna Mutis
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robbert M SpaapenTuna Mutis
Mar 6, 2010·Blood·Marie BleakleyStanley R Riddell
Jun 29, 2011·Blood·Deepika RajeshNicholas J Seay
Citations
Dec 24, 2014·Nature Communications·Kwangwoo KimSang-Cheol Bae
Nov 15, 2014·PloS One·Kwangwoo KimSang-Cheol Bae
Jul 23, 2014·Biomedical Materials·L MancusoG Cao
Apr 3, 2020·Chemical Research in Toxicology·Amanda DegnerNatalia Y Tretyakova