Hapten-specific helper T cells III. Fine specificity of the (4-hydroxy-3-nitro-phenyl)acetyl (NP)-specific response in Igh-1b mice

European Journal of Immunology
C Martinez-AlonsoR Bernabé

Abstract

Helper cells, with specificity for the haptens (4-hydroxy-3-nitro-phenyl)acetyl (NP) or (4-hydroxy-5-iodo-3-nitro-phenyl)acetyl (NIP), were raised in B10.BR mice by in vivo priming and in vitro long-term enrichment with hapten-derivatized syngeneic spleen cells. Upon co-culture with the homologous antigen (NP or NIP self), selected helper cells specifically responded by proliferation and by inducing large numbers of B cells to clonal expansion and immunoglobulin secretion. Criss-cross experiments demonstrated the nonheteroclitic nature of antigen recognition by helper cells, as the proliferative and helper cell activities were in every case one order of magnitude higher when confronted with the homologous hapten used for immunization.

References

Jan 1, 1977·Immunological Reviews·O Mäkelä, K Karjalainen
Sep 1, 1979·European Journal of Immunology·H PohlitH von Boehmer
Aug 1, 1979·European Journal of Immunology·R R BernabéA Coutinho
Feb 1, 1978·European Journal of Immunology·K Karjalainen, O Mäkelä
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Jul 1, 1976·The Journal of Experimental Medicine·M A VadasA M Whitelaw
Dec 1, 1974·The Journal of Experimental Medicine·T Imanishi, O Mäkelä
Jun 1, 1973·European Journal of Immunology·T Imanishi, O Mäkelä

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Citations

Feb 1, 1991·Research in Immunology·L PezziC Martinez
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Bikoff
Jul 1, 1982·The Journal of Experimental Medicine·W R ThomasJ F Miller
Oct 1, 1987·Scandinavian Journal of Immunology·G Andrighetto, M Zöller

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