PMID: 6167654Aug 1, 1981Paper

Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XI. Pseudogenetic restrictions of hybridoma suppressor factors

The Journal of Experimental Medicine
K OkudaM E Dorf

Abstract

Suppressor factor derived from three different murine T cell hybridomas were characterized . They specifically inhibited 4-hydroxy-3-nitrophenyl acetyl cutaneous sensitivity responses. The factors bind antigen and bear I-J and idiotypic determinants, but lack conventional immunoglobulin constant-region determinants. The factors function during the induction phase of the immune response, by inducing a second population of suppressor cells (Ts(e)). Suppressor factor can inhibit both cellular and plaque-forming cell responses in appropriate strains of mice. These hybridoma suppressor factors directly suppress strains of mice that are Igh-V homologous with the strain producing the factor. Thus, there is an apparent Igh-V restriction in the activity of these factors. However, this is a pseudogenetic restriction because these factors generate second order suppressor cells (Ts(e)) in Igh-incompatible mice, but in order to express the suppressive activity, the cells must be adoptively transferred into recipients that are Igh compatible with the strain producing the suppressor factor. Finally, it was shown that the factor-induced Ts(e) population is under an apparent dual genetic restriction. Thus, Igh and H-2 homology is required in or...Continue Reading

References

May 1, 1980·Springer Seminars in Immunopathology·R N Germain, B Benacerraf
Jan 1, 1981·Scandinavian Journal of Immunology·B Benacerraf, R N Germain

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Citations

Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M HedrickY Kaufmann
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K ZupkoB Diamond
Apr 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·C E SotomayorD T Masih
Aug 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
Nov 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
May 1, 1983·The Journal of Experimental Medicine·M MinamiM E Dorf
Jun 1, 1983·The Journal of Experimental Medicine·I AokiM E Dorf
Aug 1, 1988·International Reviews of Immunology·M E DorfR M O'Hara
Jan 1, 1982·Annals of the New York Academy of Sciences·B BenacerrafM E Dorf
Jan 1, 1982·Annals of the New York Academy of Sciences·A TominagaM I Greene
Jan 1, 1983·Annals of the New York Academy of Sciences·C J Bellone, S Jayaraman
Apr 1, 1985·Immunological Reviews·M Taniguchi, T Sumida
Mar 1, 1986·Infection and Immunity·R L MosleyR A Cox

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