PMID: 7019373Mar 1, 1981Paper

Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses

The Journal of Experimental Medicine
D H SherrM E Dorf

Abstract

The ability of suppressor cells induced by the intravenous administration of 4-hydro-3-nitrophenyl acetyl (NP)-modified syngeneic cells to reduce an idiotypic B cell response was studied in both an in vivo and an in vitro system. Idiotype-positive B cells were assayed by the ability of guinea pig anti-idiotypic antiserum to specifically inhibit idiotype-positive plaque formation. It was found that up to 57% of the PFC response in vivo and 100% of the PFC response in vitro was inhibitable with antiidiotypic antiserum. The expression of these idiotype-positive B cells could be suppressed by the transfer of spleen cells form mice treated 7 d previously with NP coupled syngeneic cels. T cells are both required and sufficient for the transfer of idiotype specific suppression. The induction of these idiotype-specific T suppressor cells directly with antigen suggests that recognition of unique determinants on cell surfaces is important for regulation of lymphoid cell interactions. The role of idiotype-specific suppressor cells in the network of lymphoid interactions is discussed.

References

Oct 1, 1976·The Journal of Experimental Medicine·D A RowleyI Lorbach
Oct 1, 1979·The Journal of Experimental Medicine·Y Dohi, A Nisonoff
Feb 1, 1978·European Journal of Immunology·K Karjalainen, O Mäkelä
May 15, 1975·Experientia·R M Zinkernagel, R V Blanden
Apr 1, 1976·The Journal of Experimental Medicine·D H KatzB Benacerraf
Jul 14, 1972·Science·B BlombergM Weigert
Dec 1, 1974·The Journal of Experimental Medicine·T Imanishi, O Mäkelä
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Cosenza, H Köhler
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

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Citations

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V K KuchrooM E Dorf
Oct 1, 1981·The Journal of Experimental Medicine·S K PierceH Köhler
May 1, 1983·The Journal of Experimental Medicine·M MinamiM E Dorf
Aug 1, 1988·International Reviews of Immunology·M E DorfR M O'Hara
Jan 1, 1982·Annals of the New York Academy of Sciences·D W ScottL A Wilson
Jun 1, 1984·Immunological Reviews·M McNamaraH Kohler
Dec 29, 1995·Annals of the New York Academy of Sciences·C D SwensonG J Thorbecke
Nov 11, 1983·Science·L V Abruzzo, D A Rowley

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