PMID: 3759906Oct 1, 1986Paper

Haptenic oligosaccharides in antigenic variants of mycobacterial C-mycosides antagonize lipid receptor activity for mycobacteriophage D4 by masking a methylated rhamnose

Journal of Bacteriology
K R DhariwalM B Goren

Abstract

The simple apolar C-mycosides, i.e., structurally well-defined hydrophobic glycopeptidolipids of several Mycobacterium species (see diagram below), were earlier shown to behave as receptors for adsorption of mycobacteriophage D4. This phage is usually virulent for Mycobacterium smegmatis. More complex, polar C-mycosides with additional carbohydrate substituents attached solely to the deoxytalose have recently been described. They are the highly specific serotyping antigens discovered by W. B. Schaefer--lipids which characterize members of the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum (MAIS) complex. Both kinds are depicted in the structure below: (Formula: see text) where X equals H (for simple, apolar C-mycosides) and X equals small oligosaccharides (for antigenic forms; more complex, polar C-mycosides). The present investigations showed that the purified polar antigenic lipids exhibit considerably less adsorptive activity for D4 than do the apolar C-mycosides. Thus, the haptenic oligosaccharides are believed to shield the site in the molecule that the phage recognizes, and the blocking is reinforced by the specific antibodies that the antigens elicit. Although the MAIS serovars usually also p...Continue Reading

References

Mar 1, 1977·Bacteriological Reviews·L Barksdale, K S Kim
Jul 27, 1979·Biochimica Et Biophysica Acta·M B Goren, R Toubiana
Oct 1, 1978·Journal of Clinical Microbiology·P J BrennanM B Goren
Jul 1, 1986·Carbohydrate Research·A Liav, M B Goren
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R T CamphausenP J Brennan
Jun 1, 1972·Journal of Virology·M B GorenO Brokl
Jan 1, 1973·Annual Review of Microbiology·A A Lindberg
Jul 29, 1971·European Journal of Biochemistry·A VoilandG Michel
May 1, 1968·Tetrahedron Letters·E Vilkas, E Lederer
Sep 24, 1968·European Journal of Biochemistry·G Laneelle, J Asselineau

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