Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage

Neurosurgery
Santosh B MurthyPaul A Nyquist

Abstract

Haptoglobin (Hp) genotype has been shown to be a predictor of clinical outcomes in subarachnoid hemorrhage. Cerebral salt wasting (CSW) has been suggested to precede the development of symptomatic vasospasm. To determine if Hp genotype was associated with CSW and subsequent vasospasm after aneurysmal subarachnoid hemorrhage. Hp genotypic determination was done for patients admitted with a diagnosis of subarachnoid hemorrhage. Outcome measures included CSW, delayed cerebral infarction, and Glasgow Outcome Score of 4 to 5 at 30 days. Criteria for CSW included hyponatremia <135 mEq/L, and urine output >4 L in 12 hours with urine sodium >40 mEq/L. A total of 133 patients were included in the study. The 3 Hp subgroups did not differ in terms of baseline characteristics. CSW occurred in 1 patient (3.4%) with Hp 1-1, 8 (14.0%) patients with Hp 2-1, and 15 (31.9%) patients with Hp 2-2 (P = .004). In the multivariate regression model, Hp 2-2 was associated with CSW (odds ratio [OR]: 4.94; CI: 1.78-17.43; P = .01), but Hp 2-1 was not (OR: 2.92; CI: 0.56-4.95; P = .15) compared with Hp 1-1. There were no associations between Hp genotypes and functional outcome or delayed cerebral infarction. CSW was associated with delayed cerebral infarc...Continue Reading

References

Feb 24, 2001·Critical Care Clinics·M R Harrigan
Mar 13, 2002·Atherosclerosis·Irit HochbergAndrew P Levy
Jun 26, 2004·Stroke; a Journal of Cerebral Circulation·Alejandro A RabinsteinEelco F M Wijdicks
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Russell P RotherMark T Gladwin
Jan 27, 2006·The New England Journal of Medicine·Jose I SuarezWarren R Selman
Jan 30, 2007·Lancet·Jan van GijnGabriel J E Rinkel
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Kaisorn L ChaichanaRafael J Tamargo
Apr 11, 2009·Stroke; a Journal of Cerebral Circulation·Jennifer A FronteraStephan A Mayer
Apr 25, 2009·Stroke; a Journal of Cerebral Circulation·Nyika D KruytYvo B W E M Roos
Mar 19, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroyuki OhnishiMasaya Ikegawa
May 9, 2013·Stroke; a Journal of Cerebral Circulation·Tiffany R ChangNeeraj S Naval
Nov 30, 2013·Journal of Neurosurgery·Ellen KantorSheila A Alexander
May 23, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Karol P BudohoskiPeter J Kirkpatrick

❮ Previous
Next ❯

Citations

Jun 22, 2018·Nature Reviews. Neurology·Diederik BultersIan Galea
Mar 3, 2018·AACN Advanced Critical Care·Megan Maserati, Sheila A Alexander
Nov 7, 2017·Oxidative Medicine and Cellular Longevity·Ben GaastraIan Galea
Oct 17, 2019·Molecular Neurobiology·Steven A RobicsekSylvain Doré
Jun 14, 2019·Oxidative Medicine and Cellular Longevity·Ardalan ZolnourianDiederik Bulters
Apr 9, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Michael R HalsteadPaul Nyquist
Feb 3, 2021·The American Journal of the Medical Sciences·John K MaesakaWayne D Comper
Apr 12, 2021·Neurosurgical Review·James FeghaliChristopher M Jackson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.