Abstract
Acute kidney injury (AKI) often occurs after cardiac surgery. During cardiac surgery, plasma free hemoglobin (fHb) would increase due to hemolysis. Since plasma fHb is thought to be nephrotoxic, haptoglobin, which is an fHb scavenger, may have the potential to prevent postoperative AKI (pAKI). However, there have been few studies in which the association of intraoperative administration of haptoglobin with the incidence of AKI after cardiac surgery was assessed. This study was a retrospective observational study to assess the independent association of intraoperative administration of haptoglobin with the incidence pAKI in cardiac surgery patients. We screened cardiac surgery patients who required cardiopulmonary bypass from 2008 to 2015. We excluded patients who required renal replacement therapy preoperatively. We also excluded patients in whom descending aortic replacement was performed. pAKI was defined according to AKI Network criteria. A propensity score-matched model was used to adjust confounders. For sensitive analysis, we further developed a logistic regression model. We included 1326 patients in this study. The incidence of AKI in the total cohort was 25.5% (338 patients). Haptoglobin was administered in 260 patients...Continue Reading
References
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mitchell H Rosner, Mark D Okusa
Dec 8, 2007·Lancet·Erik von ElmUNKNOWN STROBE Initiative
Apr 29, 2009·Circulation·Charles E HobsonAzra Bihorac
Mar 20, 2010·Molecular Immunology·Hanne Van GorpHans J Nauwynck
May 4, 2010·Anesthesia and Analgesia·Tjörvi E PerryUNKNOWN CABG Genomics Investigators
May 17, 2011·The Journal of Thoracic and Cardiovascular Surgery·Iris C Vermeulen WindsantMichael J Jacobs
Aug 30, 2011·The Annals of Thoracic Surgery·Giovanni MariscalcoAndrea Sala
Mar 2, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Samer A M NashefUlf Lockowandt
Apr 21, 2012·Hemodialysis International·Hong-Mou ShihHan-Hsiang Chen
May 15, 2013·Nature Reviews. Nephrology·A M F MartinesD W Swinkels
Jan 8, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lara S MamikonianJennifer L Turi
Sep 23, 2014·Circulation·Linda RydénMartin J Holzmann
Sep 25, 2014·Frontiers in Physiology·Iris C Vermeulen WindsantWim A Buurman
Citations
Jun 22, 2018·Nature Reviews. Neurology·Diederik BultersIan Galea
Dec 10, 2017·Hematology·Elliott Vichinsky
Mar 7, 2020·Toxicology Mechanisms and Methods·Dylan R AddisSadis Matalon
Oct 17, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Martin H BernardiMichael J Hiesmayr
Sep 28, 2017·Critical Care : the Official Journal of the Critical Care Forum·François DépretUNKNOWN PRONOBURN group
Apr 16, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Nicolas DufourMarie Thuong
Mar 14, 2020·Health Science Reports·Satoshi KimuraHiroshi Morimatsu
Jul 21, 2017·Journal of Anesthesia·Kenta KubotaSatoshi Mizobuchi
May 18, 2020·Journal of Translational Medicine·Lukas WisgrillMartin H Bernardi
Sep 26, 2020·Frontiers in Medicine·Vikram SabapathyRahul Sharma
Dec 27, 2019·Current Opinion in Anaesthesiology·David M BaronLorenzo Berra
Jan 17, 2021·The Journal of Thoracic and Cardiovascular Surgery·Betty PatUNKNOWN Clinical Working Group
Apr 19, 2020·Seminars in Nephrology·V Eric Kerchberger, Lorraine B Ware
May 31, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Mai HokkaSatoshi Mizobuchi