Haptoglobin phenotype and the risk of restenosis after coronary artery stent implantation

The American Journal of Cardiology
A RoguinAndrew P Levy

Abstract

We recently demonstrated that an allelic polymorphism in the haptoglobin gene is a major determinant of susceptibility to a number of vascular disorders. We set out to determine if haptoglobin phenotype was predictive of the development of restenosis in a consecutive series of patients, all of whom underwent stent implantation followed by repeat angiography with quantitative coronary angiography analysis 6 months later. This study included 214 consecutive patients undergoing stent implantation for de novo lesions between 1998 and 1999 in Aalst, Belgium. All underwent follow-up quantitative coronary angiography analysis 6 months after the procedure. The haptoglobin phenotype was determined by electrophoresis. No significant differences were found between patients segregated by phenotype with respect to clinical, procedural, and angiographic factors previously suggested to influence the development of restenosis. None of the diabetic patients homozygous for the haptoglobin 1 allele developed restenosis compared with a >50% restenosis rate for diabetic patients with at least 1 haptoglobin 2 allele (p <0.02). In all patients (diabetic and nondiabetic), we observed a trend toward a lower incidence of restenosis in patients homozygou...Continue Reading

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Citations

Feb 27, 2007·Vascular Health and Risk Management·Rabea Asleh, Andrew P Levy
May 18, 2004·Pathologie-biologie·P S MonraatsJ W Jukema
Sep 8, 2007·European Journal of Internal Medicine·Sahar S BessaEhab M M Ali
Aug 31, 2004·Diabetes Care·Stefan MustafaAlexandra Kautzky-Willer
May 21, 2016·Future Cardiology·Karen L Graves, David J Vigerust
Sep 22, 2016·Antioxidants & Redox Signaling·Christian Brix Folsted AndersenSøren Kragh Moestrup
May 11, 2017·Stroke; a Journal of Cerebral Circulation·Petra IjäsTimo Erkinjuntti
Apr 27, 2005·Diabetes/metabolism Research and Reviews·Rachel Miller-LotanAndrew P Levy
Oct 27, 2004·Clinical Chemistry·Nina S Levy, Andrew P Levy
May 27, 2004·Clinical Chemistry·Sayed M H SadrzadehJafar Bozorgmehr
Oct 28, 2003·Clinical Chemistry·Werner KochAdnan Kastrati
Jan 8, 2020·Brain Sciences·Juha LempiäinenSusanna Melkas
May 28, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chun Yi LiauSimon J T Mao
Sep 14, 2016·Clinical Diabetes : a Publication of the American Diabetes Association·Mark MacKellar, David J Vigerust

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