Haptoglobin phenotype, angiogenic factors, and preeclampsia risk.

American Journal of Obstetrics and Gynecology
T L WeissgerberR E Gandley

Abstract

We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF). Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum. Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes. Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.

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Citations

Dec 12, 2012·Journal of Human Hypertension·J T SertórioJ E Tanus-Santos
Apr 11, 2013·PloS One·Tracey L WeissgerberUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Dec 19, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tracey L WeissgerberUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Aug 15, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Piya ChaemsaithongTinnakorn Tinnakorn
May 31, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·T L WeissgerberUNKNOWN Diabetes and Pre-eclampsia Intervention Trial (DAPIT) Study Group
Oct 23, 2010·PloS One·Arun JeyabalanUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
May 22, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tinnakorn ChaiworapongsaSonia S Hassan
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Clare B KellyTimothy J Lyons
Nov 5, 2019·American Journal of Reproductive Immunology : AJRI·Tino W SanchezEugenia Mata-Greenwood
Mar 21, 2017·Archives of Gynecology and Obstetrics·Mutong ZhaoZhenyu Zhang
Mar 4, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohammad S GhaemiMartin S Angst

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