Haptoglobin phenotype appears to affect the pathogenesis of American trypanosomiasis

Annals of Tropical Medicine and Parasitology
D R CalderoniH Z W Grotto

Abstract

In Latin America, 16 million-18 million people are thought to be infected with Trypanosoma cruzi, the parasite that causes American trypanosomiasis. The pathophysiology of this disease, particularly that of its chronic phase, has yet to be fully elucidated. The major function of haptoglobin, an acute-phase plasma protein found in three different phenotypes (Hp1-1, Hp2-1 and Hp2-2), is to bind to free haemoglobin and so prevent the accumulation of reactive hydroxyl radicals and renal damage. The haptoglobin phenotype present can influence the severity and progression of many diseases, including infectious ones. The aim of the present study was to see if any haptoglobin phenotype could be associated with any of the various clinical forms of American trypanosomiasis, and so explore the possibility that haptoglobin and iron metabolism have a role in the pathophysiology of this disease. The Brazilian subjects investigated were either suffering from the 'indeterminate' (N=16), chronic cardiac (N=34), chronic digestive (N=13) or chronic 'combined' (i.e. cardiac plus digestive; N=29) forms of the disease or were apparently healthy blood donors from the same region as the patients (N=197). Haptoglobin phenotypes were determined by polya...Continue Reading

Citations

Jul 1, 2009·Genetics and Molecular Biology·Ana L Miranda-VilelaMaria N Klautau-Guimarães
Aug 26, 2014·Disease Markers·Ninomar Mundaray Fernández, Mercedes Fernández-Mestre
Oct 7, 2009·Clinical Biochemistry·Susan E D C JorgeMaria de Fatima Sonati
May 4, 2007·International Journal of Laboratory Hematology·Kymberley Carter, Mark Worwood
Mar 26, 2019·PLoS Neglected Tropical Diseases·Elvis OfonUNKNOWN TrypanoGEN Research Group, as members of The H3Africa Consortium
Apr 20, 2017·Annals of the New York Academy of Sciences·Craig SturgeonAlessio Fasano
Dec 25, 2010·Ciência & saúde coletiva·Guilherme Loureiro WerneckThaise Gasser Gouvêa

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