Hard tissue regeneration capacity of apical pulp derived cells (APDCs) from human tooth with immature apex

Biochemical and Biophysical Research Communications
Shigehiro AbeTeruo Amagasa

Abstract

Recent studies indicate that dental pulp is a new source of adult stem cells. The human tooth with an immature apex is a developing organ, and the apical pulp of this tooth may contain a variety of progenitor/stem cells, which participate in root formation. We investigated the hard tissue regeneration potential of apical pulp derived cells (APDCs) from human tooth with an immature apex. APDCs cultured with a mineralization-promoting medium showed alkaline phosphatase activity in porous hydroxyapatite (HA) scaffolds. The composites of APDCs and HA were implanted subcutaneously in immunocompromised rats and harvested at 12 weeks after implantation. In histological analysis, the APDCs/HA composites exhibited bone- and dentine-like mineralized tissues in the pore areas of HA. This study suggests that the human tooth with an immature apex is an effective source of cells for hard tissue regeneration.

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Citations

May 24, 2011·Journal of Materials Science. Materials in Medicine·Sandra Viale-BouroncleChristian Morsczeck
May 11, 2010·International Journal of Dentistry·Weibo Zhang, Pamela C Yelick
Jun 6, 2009·Journal of Dental Research·S A Hacking, A Khademhosseini
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Jun 27, 2012·Cell Biology International·Shigehiro AbeSatoshi Yamaguchi
Jun 6, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rafael Lima Verde OsterneRenato Luiz Maia Nogueira
Oct 18, 2016·International Journal of Implant Dentistry·Martin GosauChristian Morsczeck
Sep 18, 2012·Archives of Oral Biology·Nobuyuki Kawashima
Nov 20, 2015·Stem Cells Translational Medicine·Shigehiro AbeKiyoshi Harada
Jun 1, 2019·Biofabrication·Olivia KérourédanRaphaël Devillard
Jan 10, 2019·Journal of Clinical Periodontology·Mark BartoldSaso Ivanovski
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Mar 31, 2021·Trends in Molecular Medicine·Weibo Zhang, Pamela C Yelick
Nov 11, 2020·Archives of Oral Biology·Aline QueirozMarília Trierveiler

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