Hard to wake up? The cerebral correlates of sleep inertia assessed using combined behavioral, EEG and fMRI measures

NeuroImage
Raphael VallatPerrine Ruby

Abstract

The first minutes following awakening from sleep are typically marked by reduced vigilance, increased sleepiness and impaired performance, a state referred to as sleep inertia. Although the behavioral aspects of sleep inertia are well documented, its cerebral correlates remain poorly understood. The present study aimed at filling this gap by measuring in 34 participants the changes in behavioral performance (descending subtraction task, DST), EEG spectral power, and resting-state fMRI functional connectivity across three time points: before an early-afternoon 45-min nap, 5 min after awakening from the nap and 25 min after awakening. Our results showed impaired performance at the DST at awakening and an intrusion of sleep-specific features (spectral power and functional connectivity) into wakefulness brain activity, the intensity of which was dependent on the prior sleep duration and depth for the functional connectivity (14 participants awakened from N2 sleep, 20 from N3 sleep). Awakening in N3 (deep) sleep induced the most robust changes and was characterized by a global loss of brain functional segregation between task-positive (dorsal attention, salience, sensorimotor) and task-negative (default mode) networks. Significant c...Continue Reading

Citations

Aug 20, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea N Goldstein-PiekarskiLeanne M Williams
Oct 17, 2019·Nature Reviews. Neuroscience·Antoine R AdamantidisThomas C Gent
Apr 23, 2020·Frontiers in Physiology·Katya KovacGrace E Vincent
Oct 16, 2018·Frontiers in Psychology·Raphael VallatPerrine Ruby
Jan 21, 2021·Brain Sciences·Farzad V FarahaniTadeusz Marek
Mar 20, 2021·Frontiers in Neuroscience·Andrea I LuppiEmmanuel A Stamatakis
Jul 14, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Santiago AlcaidePablo Barttfeld
Aug 7, 2021·Journal of Forensic and Legal Medicine·Rosemary Alison IsaacsDavid James Templeton

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