Harding-passey mouse-melanoma tyrosinase inactivation by reaction products and activation by L-epinephrine

General Pharmacology
M Miranda, D Botti

Abstract

1. Harding-Passey mouse-melanoma tyrosinase (EC 1.14.18.1) is inhibited during L-3,4-dihydroxyphenylalanine oxidation by reaction products. L-3,4-dihydroxyphenyl 3-[14C]alanine oxidation products bind to the enzyme, as demonstrated by gel electrophoresis and radioactivity measurements. 2. The enzyme interacts with indoles and oxidizes dopamine and norepinephrine. 3. L-epinephrine activates tyrosinase at non hormonal concentrations and bovine serum albumin protects the enzyme from auto-inhibition. 4. The inhibition of the Harding-Passey mouse-melanoma tyrosinase, during substrate oxidation, is very similar to that of mushroom enzyme.

References

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Citations

Jul 7, 1987·Biochimica Et Biophysica Acta·M MirandaG del Boccio
Jan 11, 1994·Biochimica Et Biophysica Acta·C SalinasJ A Lozano
Aug 16, 1985·Biochimica Et Biophysica Acta·M MirandaA Arcadi
Jan 1, 1984·General Pharmacology·M MirandaA Arcadi
Jul 31, 2007·The Tohoku Journal of Experimental Medicine·Edward J LandPatrick A Riley
May 19, 2010·International Journal of Molecular Sciences·Takafumi Hasegawa
Sep 5, 2008·Neurochemical Research·Ikuko Miyazaki, Masato Asanuma
Mar 19, 2005·Journal of Neurochemistry·Elisa GreggioMark R Cookson
Aug 25, 2007·Biochemical and Biophysical Research Communications·David VauzourJeremy P E Spencer
Aug 23, 2011·Behavioural Processes·Yutaka Yamamuro, Aya Shiraishi
Sep 27, 2003·Journal of Neurochemistry·Takafumi HasegawaYasuto Itoyama
Jun 4, 2004·The Journal of Comparative Neurology·Daisuke SakuraiMotoyuki Tsuda
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Jan 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ikuko MiyazakiNorio Ogawa
Sep 15, 2000·Journal of Neurochemistry·Y HigashiN Ogawa

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