PMID: 702286Oct 1, 1978Paper

Hardness increase induced by partial moisture loss in compressed tablets and its effect on in vitro dissolution

Journal of Pharmaceutical Sciences
Z T Chowhan, L Palagyi

Abstract

The hardness increase induced by partial moisture loss in compressed tablets was studied. Several factors such as the type and percentage of the excipient, the water solubility and hygroscopicity of the excipient or drug, and the influence of frequently used binders were investigated. The results indicate that the tablets increased in hardness by the recrystallization of the soluble excipient or the soluble drug in the void spaces This recrystallization occurred because of the moisture loss after expulsion of the solution of the excipient or drug in the void spaces on compression. The large increase in hardness induced by the partial moisture loss did not decrease in vitro dissolution appreciably. This result was clearly different from the hardness increase caused by higher compression loads in the absence of a moisture-induced effect, which showed a decrease in the in vitro dissolution as the hardness was increased.

References

Nov 1, 1971·Journal of Pharmaceutical Sciences·J E Rees, E Shotton

❮ Previous
Next ❯

Citations

Feb 24, 1989·Pharmaceutisch Weekblad. Scientific Edition·T PesonenT Puurunen
Jan 24, 2009·Pharmaceutical Research·Vivian GrayStephen Mayock
Aug 25, 1999·Drug Development and Industrial Pharmacy·B Kommanaboyina, C T Rhodes
Dec 12, 2013·Journal of Pharmaceutical Sciences·Mark Sacchetti
Dec 1, 1982·Journal of Pharmaceutical Sciences·Z T ChowhanL H Chi
Oct 1, 1981·Journal of Pharmaceutical Sciences·Z T Chowhan, Y P Chow
May 16, 2000·Pharmaceutical Development and Technology·J RantanenJ Yliruusi
Aug 26, 2000·Journal of Biopharmaceutical Statistics·J M Reynolds, D H Rogers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.