Hark back: passive immunotherapy for influenza and other serious infections

Critical Care Medicine
Thomas C LukeTimothy H Burgess


The world is experiencing a pandemic of swine-origin influenza virus H1N1. A vaccine to prevent disease is now available, and millions have or will become ill before they can be vaccinated. The ability to use swine-origin influenza virus vaccines as a public health tool has been described as a "race against time." Oseltamivir and related drugs are being used in an effort to reduce morbidity and mortality, but their efficacy for treating severe influenza is suboptimal, and possible wide-spread emergence of oseltamivir-resistant mutants is a concern. Another approach for prevention and treatment of serious influenza is infusion of hyperimmune plasma. The United States has thousands of licensed blood product collection centers that produce millions of liters of plasma licensed by the Food and Drug Administration on an annual basis for the treatment of serious conditions. Immunotherapy using infusion of convalescent plasma (or hyperimmune intravenous immunoglobulin) has been reported to be an effective treatment for severe influenza and other virulent pathogens in animal models and humans. Plasma obtained from those that have recovered or were early recipients of vaccine offers a resource for production of an immediately available ...Continue Reading


Jun 1, 1977·American Journal of Diseases of Children·H H BalfourJ S Najarian
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·P B JahrlingM H Monson
Aug 1, 1971·The Journal of Pediatrics·R C BalagtasS P Gotoff
Jan 1, 1984·Vox Sanguinis·C W Walter
Jul 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, M D Scharff
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·A Casadevall, M D Scharff
Oct 1, 1993·Transplantation·B NourT E Starzl
Dec 16, 1993·The New England Journal of Medicine·D SamuelH Bismuth
Feb 13, 1999·The Journal of Infectious Diseases·N M Kudoyarova-ZubavicheneS V Netesov
Oct 16, 2002·Thrombosis Research·Peter HellsternBjarte G Solheim
Jun 17, 2004·British Journal of Haematology·D F O'ShaughnessyUNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Jun 18, 2004·Emerging Infectious Diseases·Jann-Tay WangPan-Chyr Yang
Jun 25, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y O Y SooJ J Y Sung
Dec 24, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ChengG Cheng
Mar 4, 2005·Journal of the Chinese Medical Association : JCMA·Cheng-Yu ChenReury-Perng Perng
Mar 1, 1937·The Journal of Clinical Investigation·A C McGuinnessS Mudd
Aug 31, 2006·Annals of Internal Medicine·John J Treanor
Aug 31, 2006·Annals of Internal Medicine·Thomas C LukeStephen L Hoffman
Sep 14, 2006·PLoS Medicine·Lauren J StockmanPaul Garner
Oct 5, 2007·The New England Journal of Medicine·Boping ZhouYi Guan
Dec 6, 2007·The Journal of Infectious Diseases·Peter B JahrlingThomas W Geisbert
Dec 7, 2007·Antiviral Research·Delia A EnriaZaida Sánchez
Mar 4, 2009·JAMA : the Journal of the American Medical Association·Nila J DharanUNKNOWN Oseltamivir-Resistance Working Group
Sep 30, 1932·The Journal of Experimental Medicine·M Brodie

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Mar 30, 2012·The Journal of Infectious Diseases·Mathieu BangertAras Kadioglu
Feb 22, 2012·Critical Care Medicine·John H Beigel, Thomas C Luke
Oct 21, 2014·Influenza Research and Treatment·Cassandra M BerryMark Y Sangster
Jan 19, 2016·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O GarraudS Laperche
Feb 19, 2016·Science Translational Medicine·Thomas LukeMatthew B Frieman
Aug 1, 2014·Expert Opinion on Biological Therapy·Ali Khamesipour
Mar 24, 2012·Current Opinion in Virology·Michael G Ison
Aug 12, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johan van GriensvenLutgarde Lynen
Apr 24, 2015·PLoS Pathogens·Arturo Casadevall, Liise-Anne Pirofski
May 15, 2015·Clinical Microbiology Reviews·Gary Wong, Gary P Kobinger
Oct 10, 2018·Current Opinion in Infectious Diseases·John H Beigel
Mar 14, 2020·The Journal of Clinical Investigation·Arturo Casadevall, Liise-Anne Pirofski
Jan 21, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ivan Fn HungKwok-Yung Yuen
Jul 4, 2020·MBio·Liise-Anne Pirofski, Arturo Casadevall
Jul 8, 2020·The Journal of Clinical Investigation·Arturo CasadevallLiise-Anne Pirofski
Sep 9, 2017·Tropical Diseases, Travel Medicine and Vaccines·John W Sanders, Todd A Ponzio
Sep 17, 2020·Signal Transduction and Targeted Therapy·Yongzhi Xi
Aug 25, 2020·SN Comprehensive Clinical Medicine·Ramtin PourahmadNima Rezaei
Aug 12, 2020·Archives of Virology·Saba ShamimGhulam Murtaza
Dec 8, 2020·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Barsha DassarmaMotlalepula Matsabisa
Sep 10, 2020·Journal of Infection and Public Health·Basavraj NagobaSohan Selkar
Dec 3, 2020·Risk Management and Healthcare Policy·Nandeeta SamadMainul Haque
Feb 2, 2021·The New England Journal of Medicine·Michael J JoynerArturo Casadevall
Feb 13, 2021·Biologics : Targets & Therapy·Massimo Franchini, Giancarlo Maria Liumbruno
Mar 3, 2021·Diagnosis·Massimo FranchiniGiancarlo Maria Liumbruno
Jul 11, 2020·HemaSphere·Theodora PsaltopoulouMeletios A Dimopoulos
Feb 12, 2020·Cold Spring Harbor Perspectives in Medicine·John H Beigel, Frederick G Hayden
Dec 29, 2020·Med·Arturo CasadevallNigel Paneth
Apr 28, 2021·Hematology, Transfusion and Cell Therapy·Sumit Saha, Sachin Kadam
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