Harm and benefits of primary liver resection and salvage transplantation for hepatocellular carcinoma

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Alessandro CucchettiAntonio Pinna

Abstract

Primary transplantation offers longer life-expectancy in comparison to hepatic resection (HR) for hepatocellular carcinoma (HCC) followed by salvage transplantation; however, livers not used for primary transplantation can be reallocated to the remaining waiting-list patients, thus, the harm caused to resected patients could be balanced, or outweighed, by the benefit obtained from reallocation of livers originating from HCC patients first being resected. A Markov model was developed to investigate this issue based on literature data or estimated from the United Network for Organ Sharing database. Markov model shows that primary transplantation offers longer life-expectancy in comparison to HR and salvage transplantation if 5-year posttransplant survival remains higher than 60%. The balance between the harm for resected patients and the benefit for the remaining waiting list depends on (a) the proportion of HCC candidates, (b) the percentage shifted to HR and (c) the median expected time-to-transplant. Faced with a low proportion of HCC candidates, the harm caused to resected patients was higher than the benefit that could be obtained for the waiting-list population from re-allocation of extra livers. An increased proportion of ...Continue Reading

References

Dec 1, 1982·The American Journal of Medicine·J R BeckS G Pauker
Dec 13, 1995·JAMA : the Journal of the American Medical Association·G H GuyattR J Cook
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F P SarasinA Hadengue
Apr 2, 2002·The American Journal of Gastroenterology·Franco TrevisaniUNKNOWN Italian Liver Cancer Group
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Nov 12, 2003·Archives of Surgery·Hiroshi ImamuraMasatoshi Makuuchi
Nov 19, 2003·Annals of Internal Medicine·Hashem B El-SeragKatherine A McGlynn
Nov 25, 2003·Annals of Surgery·Jacques BelghitiReza Kianmanesh
Oct 28, 2004·Gastroenterology·Russell H WiesnerDavid C Mulligan
Oct 28, 2004·Gastroenterology·F Xavier BoschRamon Cléries
Nov 24, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Manish G AminJohn B Wong
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert M MerionRobert A Wolfe
Sep 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlos MargaritItxarone Bilbao
Feb 21, 2006·Journal of Hepatology·Umberto CilloDavide Francesco D'Amico
Jun 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P SharmaV Balan
Jun 27, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Evangelos CholongitasAndrew K Burroughs
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RavaioliA D Pinna
Sep 5, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Richard B FreemanErick Edwards
Jun 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fabio PiscagliaLuigi Bolondi
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Morris Sherman
Mar 6, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M L VolkJ A Marrero
Mar 14, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jing-Houng WangSheng-Nan Lu
May 1, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Del GaudioA D Pinna
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James D PerkinsJorge D Reyes
Mar 21, 2009·Journal of Hepato-biliary-pancreatic Surgery·Shinichi UenoUNKNOWN Kagoshima Liver Cancer Study Group
Apr 4, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D E SchaubelR M Merion

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Citations

Feb 1, 2012·Langenbeck's Archives of Surgery·F CauchyJ Belghiti
Jun 20, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·P PuneetDarius F Mirza
Jun 2, 2012·World Journal of Gastroenterology : WJG·Hong-Yu LiBo Li
Dec 1, 2012·World Journal of Gastroenterology : WJG·Alessandro CucchettiAntonio Daniele Pinna
Nov 22, 2013·World Journal of Gastroenterology : WJG·Marco VivarelliAndrea Risaliti
Jan 11, 2014·World Journal of Gastroenterology : WJG·Alessandro VitaleUmberto Cillo
May 17, 2014·World Journal of Gastroenterology : WJG·Matteo RavaioliAntonio Daniele Pinna
Dec 3, 2014·Clinics in Liver Disease·Laura M Kulik, Attasit Chokechanachaisakul
Jun 18, 2011·Digestive Diseases and Sciences·Hongyu Li, Bo Li
Jan 26, 2012·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F RauchfussU Settmacher
Mar 6, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro CucchettiAntonio Daniele Pinna
Aug 13, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alessandro CucchettiAntonio Daniele Pinna
Mar 22, 2012·Alimentary Pharmacology & Therapeutics·J R L MaggsM A Heneghan
Aug 1, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Zhenhua HuShu-Sen Zheng
May 28, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Alessandro CucchettiAntonio Daniele Pinna
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David FuksJacques Belghiti
Jan 17, 2015·Frontiers in Surgery·Zenichi MoriseMasashi Isetani
May 23, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·UNKNOWN Korean Liver Cancer Study Group (KLCSG), UNKNOWN National Cancer Center, Korea (NCC)
Aug 7, 2018·Annals of Surgery·Antonio Daniele PinnaAlessandro Cucchetti
Feb 19, 2015·International Surgery·Jigjidsuren ChinburenPuntsagdulam Natsagnyam
Mar 8, 2011·Current Opinion in Gastroenterology·Saleh A Alqahtani, Anne M Larson
Mar 28, 2012·Current Opinion in Gastroenterology·Saleh A Alqahtani
Oct 24, 2014·World Journal of Gastroenterology : WJG·Zenichi MoriseMasashi Isetani
Mar 31, 2017·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rahul Kakodkar
Jun 6, 2018·Gastroenterología y hepatología·Fernando PardoJavier Briceño

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