Harm avoidance and cerebral infarction

Neuropsychology
Robert S WilsonDavid A Bennett

Abstract

Harm avoidance, a trait indicative of behavioral inhibition, is associated with disability and dementia in old age, but the basis of these associations is uncertain. We test the hypothesis that higher level of harm avoidance is associated with increased likelihood of cerebral infarction. Older persons without dementia completed a standard measure of harm avoidance. During a mean of 3.5 years of follow-up, 257 (of 1,082) individuals died of whom 206 (80%) underwent brain autopsy. The number of chronic cerebral infarcts (microscopic plus gross; expressed as 0, 1, or >1) was assessed on neuropathologic examination, completed in 192 individuals at the time of analyses. On postmortem examination, chronic cerebral infarcts were found in 89 (42 with 1, 47 with >1). Higher harm avoidance was associated with higher likelihood of infarcts (odds ratio = 1.083, 95% confidence interval = 1.040-1.128). A moderately high level of the trait (score = 17, 75th percentile) was associated with a 2.4-fold increase in the likelihood of infarction compared with a moderately low level of the trait (score = 6, 25th percentile). These associations persisted in models that controlled for other cardiovascular risk factors. Higher level of the harm avoidan...Continue Reading

Citations

Dec 21, 2013·Acta Neuropathologica·David A BennettJulie A Schneider
Jun 4, 2016·Neurobiology of Aging·Jason HassenstabJohn C Morris
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·David A BennettJulie A Schneider
Mar 21, 2015·Stroke; a Journal of Cerebral Circulation·Lei YuDavid A Bennett
Jan 16, 2019·Annual Review of Public Health·Bryan D James, David A Bennett
Dec 3, 2020·International Journal of Behavioral Medicine·Hirokazu TakizawaToyohiro Hamaguchi
Oct 16, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·David A Bennett

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