Harmonic phase angle as a concentration-independent measure of nanoparticle dynamics.

Medical Physics
Adam M Rauwerdink, John B Weaver

Abstract

The harmonic spectrum of magnetic nanoparticles contains valuable information about the quantity and environment of the particles. Harmonic amplitudes have been used to produce quantitative images and ratios of these amplitudes have been used to monitor changes in the particle environment. Harmonic phase angles have not yet been utilized in these pursuits. The authors explore harmonic phase angle as a concentration-independent means of remotely monitoring the dynamic magnetization of nanoparticles. A magnetic nanoparticle spectrometer was used to explore the impacts of viscosity and excitation frequency and amplitude on the phase angle of magnetization harmonics. A dynamic model, which accounts for particle relaxation times, was used to model some results. Harmonic phase angle can undergo large changes when a nanoparticle's Brownian motion is altered. Excitation parameters and particle characteristics have a profound effect on the extent of these changes. Phase angle can allow for monitoring of various impacts on a nanoparticle's Brownian motion. When combined with other concentration-independent metrics, such as ratios of harmonic amplitudes, valuable information about the particle's environment can be gathered.

References

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Sep 11, 2009·Physics in Medicine and Biology·Adam M RauwerdinkJohn B Weaver

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Citations

Sep 5, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Andrew J GiustiniJohn B Weaver
Oct 16, 2010·Nanotechnology·Adam M RauwerdinkJohn B Weaver
Feb 8, 2013·Medical Physics·Michael A MartensMark Griswold
Apr 28, 2011·Medical Physics·Adam M Rauwerdink, John B Weaver
Apr 28, 2011·Medical Physics·R Matthew FergusonKannan M Krishnan
Sep 13, 2012·IEEE Transactions on Medical Imaging·Laura R CroftSteven M Conolly
Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Sep 6, 2017·Physics in Medicine and Biology·Yipeng ShiJohn B Weaver
Nov 28, 2013·Biomedizinische Technik. Biomedical Engineering·Martin A RückertVolker C Behr
Aug 16, 2013·Biomedizinische Technik. Biomedical Engineering·John B WeaverIrina M Perreard
Sep 19, 2012·Advanced Materials·Patrick William GoodwillSteven M Conolly
Feb 11, 2021·ACS Applied Materials & Interfaces·Kai WuJian-Ping Wang
Mar 10, 2020·ACS Applied Materials & Interfaces·Kai WuJian-Ping Wang

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