Harmonization of units and reference intervals of plasma proteins: state of the art from an External Quality Assessment Scheme

Clinical Chemistry and Laboratory Medicine : CCLM
Sandra SecchieroMario Plebani

Abstract

The need to harmonize laboratory information is particularly intense in the field of plasma proteins, considering their clinical impact and relevance in monitoring diseases. We evaluated units and reference intervals (RIs) utilized by participants of the External Quality Assessment Scheme (EQAS) for plasma proteins of the Centre of Biomedical Research. Moreover, we evaluated inter-laboratory analytical variability from 2001 to 2017. The census of participants' units employed in 2017 showed that for albumin (ALB), ~66% of laboratories still used dL instead of L, and for most other proteins, ~70% still expressed the results in mg/dL. Laboratories primarily used the RIs reported in the packaging inserts of their analytical systems, but for each protein, there was a wide variability of RIs, also among laboratories using the same analytical method. Mean CVs% of the 13 certified proteins in the last five EQA cycles ranged from 3.8% of haptoglobin (HPT) to 12.4% of α1-antitrypsin (AAT) and decreased from 2001 to 2017 for most of them, in particular for C3, ALB, α2-macroglobulin (A2M), HPT and transferrin (TRF). In the face of a reduction in inter-laboratory variability for a lot of proteins, there has not been a substantial change in ...Continue Reading

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Citations

Jul 10, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Mario PlebaniJillian R Tate

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