Harnessing albumin as a carrier for cancer therapies

Advanced Drug Delivery Reviews
Ella N Hoogenboezem, Craig L Duvall

Abstract

Serum albumin, a natural ligand carrier that is highly concentrated and long-circulating in the blood, has shown remarkable promise as a carrier for anti-cancer agents. Albumin is able to prolong the circulation half-life of otherwise rapidly cleared drugs and, importantly, promote their accumulation within tumors. The applications for using albumin as a cancer drug carrier are broad and include both traditional cancer chemotherapeutics and new classes of biologics. Strategies for leveraging albumin for drug delivery can be classified broadly into exogenous and in situ binding formulations that utilize covalent attachment, non-covalent association, or encapsulation in albumin-based nanoparticles. These methods have shown remarkable preclinical and clinical successes that are examined in this review.

Citations

Apr 24, 2019·The Journal of Pharmacology and Experimental Therapeutics·A R Satvik IyengarAbhay H Pande
Sep 10, 2019·Expert Opinion on Drug Delivery·Sadia SikderDhananjay Pal
Aug 17, 2019·Chemistry : a European Journal·Alberto Dal CorsoCesare Gennari
Dec 6, 2019·International Journal of Molecular Sciences·Jacob W ShrefflerAmanda E Brooks
Dec 21, 2019·Drug Delivery·Leen Van de SandeWim Ceelen
Jan 10, 2020·Archives of Pharmacal Research·Shrawani Lamichhane, Sangkil Lee
May 8, 2020·Small·Nan ZhangYanli Zhao
Jun 2, 2020·Expert Opinion on Drug Delivery·Rosana Simón-VázquezÁfrica González-Fernández
Aug 18, 2020·International Journal of Nanomedicine·Zhong WanHai Zhang
Jan 8, 2021·Frontiers in Immunology·Wei LiMin Cui
Sep 2, 2020·Advanced Drug Delivery Reviews·Anastasia VarankoAshutosh Chilkoti
Dec 16, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Camilla Kaas FrichAlexander N Zelikin
Oct 19, 2020·International Journal of Pharmaceutics·Yuan LiHuile Gao
Oct 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haroon IqbalHuabing Chen
Jan 22, 2021·The Journal of Physical Chemistry. B·Nurul Ain AzmanJames Chen Yong Kah
Jan 23, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yuanhao LiangYufeng Liu
Feb 16, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jiali GuTing Sun
Dec 22, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Namdev DhasTejal Mehta
Feb 23, 2021·Frontiers in Pharmacology·Agnese GagliardiDonato Cosco
Feb 22, 2021·Drug Delivery and Translational Research·Anvay UkidveSamir Mitragotri
Mar 13, 2021·Advanced Therapeutics·Changjun YuXiaojiang Cui
Mar 20, 2021·Colloids and Surfaces. B, Biointerfaces·Subhashini BharathalaPankaj Sharma
Sep 22, 2020·Current Opinion in Chemical Engineering·Alexander G SoretsEthan S Lippmann
Apr 1, 2021·Molecular Pharmaceutics·Alessandra SpadaAfsaneh Lavasanifar
Apr 1, 2021·Neurochemistry International·Buket Ucar
Mar 31, 2021·AAPS PharmSciTech·Nidhi PatelChalet Tan
Apr 4, 2021·International Journal of Molecular Sciences·Haoyu XiongSarah D Diermeier
Apr 4, 2021·Antioxidants·Fuka TabataKazuhiro Miyaji
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
Apr 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Libin JiangMingdong Huang
May 8, 2021·Experimental Biology and Medicine·Noah Trac, Eun Ji Chung
May 13, 2021·Chemical Communications : Chem Comm·Axel SteinbrueckJonathan L Sessler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular and Cellular Therapies
Maja Thim LarsenKenneth A Howard
Cancer Control : Journal of the Moffitt Cancer Center
G N HortobagyiE K Rowinsky
Gan no rinsho. Japan journal of cancer clinics
Y SAKURAI
Current Pharmaceutical Design
Fitya Syarifa Mozar, Ezharul Hoque Chowdhury
Journal of Controlled Release : Official Journal of the Controlled Release Society
Rui Xue ZhangXiao Yu Wu
© 2022 Meta ULC. All rights reserved