Harnessing Plant Biodiversity for the Discovery of Novel Anticancer Drugs Targeting Microtubules

Frontiers in Plant Science
Songbo Xie, Jun Zhou

Abstract

The microtubule cytoskeleton plays a critical role in a wide range of cellular activities and has been shown to be a highly effective target for the treatment of human malignancies. Despite the recent focus on proteomics and high-throughput profiling, it is clear that analysis of plant extracts has yielded several highly efficacious microtubule-targeting agents (MTAs) currently in clinical use, as well as agents in the current pipeline with promising efficacy. To date, a large proportion of the world's plant biodiversity remains untapped by the pharmaceutical industry, presenting a major opportunity for the discovery of novel pharmacologically active lead compounds. Because plants contain an astonishing array of structurally diverse molecules, they represent an ideal source for the discovery of novel MTA leads. To demonstrate the importance of searching for novel bioactive compounds across the plant kingdom, herein, we summarize the discovery and development of plant-derived MTAs and discuss the challenges associated with searching for novel bioactive compounds from plants. We propose potential solutions to these problems with the aim of facilitating further exploration and identification of novel MTAs from plant biodiversity.

References

Dec 5, 1958·Annals of the New York Academy of Sciences·R L NOBLEJ H CUTTS
Jan 1, 2008·Journal of Natural Products·Laura OttaggioMariangela Miele
Oct 5, 2010·Nature Reviews. Drug Discovery·Charles Dumontet, Mary Ann Jordan
Aug 2, 2011·Journal of Medicinal Chemistry·Jiangnan PengSusan L Mooberry
Jan 5, 2013·Science·Andrea E ProtaMichel O Steinmetz
Oct 9, 2013·American Journal of Therapeutics·John StackGeraldine McCarthy
Feb 5, 2014·Bioorganic & Medicinal Chemistry·Jing LiSusan L Mooberry
Jan 3, 2015·The American Journal of Medicine·Anastasia SlobodnickSvetlana Krasnokutsky
May 27, 2015·Anti-cancer Agents in Medicinal Chemistry·Pravin O PatilShital S Naphade
Sep 17, 2015·Nature Reviews. Molecular Cell Biology·Paul T ConduitJordan W Raff
Oct 21, 2015·Frontiers in Plant Science·Marcelo FridlenderHinanit Koltai
Nov 13, 2015·Nature Reviews. Molecular Cell Biology·Anna Akhmanova, Michel O Steinmetz
Dec 19, 2015·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Gordon M Cragg, John M Pezzuto
Dec 27, 2015·Pharmacology & Therapeutics·Ying ZhaoGuanhua Du
Mar 22, 2016·F1000Research·Ryoma Ohi, Marija Zanic
Oct 1, 2016·Pharmacological Reports : PR·Karol JarochStanisław Sobiak

❮ Previous
Next ❯

Citations

Jun 24, 2017·Journal of Cellular Biochemistry·Xiao-Qian MengJun Zhou
Jun 22, 2018·Thoracic Cancer·Min LiuJun Zhou
Oct 13, 2018·Thoracic Cancer·Miao Chen, Songbo Xie
Oct 27, 2018·Journal of Cellular Physiology·Songbo XieMin Liu
Jan 13, 2018·Biology Letters·Wei Xie, Jun Zhou
Feb 6, 2020·Thoracic Cancer·Dan DongMin Liu
Sep 8, 2020·Thoracic Cancer·Jingrui LiSongbo Xie
Sep 19, 2018·Nanomaterials·Min JiaHongyan Zhang
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinhui XuLin Tang
Dec 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Marbelis Francisco FernandezBorhane Annabi
Apr 25, 2019·Cells·Robert H Whitaker, William J Placzek
Dec 27, 2017·Thoracic Cancer·Shuang Sun, Jun Zhou
May 15, 2018·Frontiers in Pharmacology·Fazilath UzmaElsayed F Abd Allah
Feb 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kamel A SalehAbdullah D A Alasmari
Jun 21, 2019·Journal of Cellular Physiology·Feifei QiMin Liu
Jan 30, 2021·Journal of Biochemical and Molecular Toxicology·Jinglei LiuYulong Shi
Oct 31, 2018·Open Life Sciences·Songbo Xie, Min Liu
Apr 8, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kelly A ShipkowskiCynthia V Rider
May 1, 2021·Biomedicines·Søren Brøgger Christensen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved