Harnessing plant metabolic diversity

Current Opinion in Chemical Biology
Charlie OwenAnne Osbourn

Abstract

Advances in DNA sequencing and synthesis technologies in the twenty-first century are now making it possible to build large-scale pipelines for engineering plant natural product pathways into heterologous production species using synthetic biology approaches. The ability to decode the chemical potential of plants by sequencing their transcriptomes and/or genomes and to then use this information as an instruction manual to make drugs and other high-value chemicals is opening up new routes to harness the vast chemical diversity of the Plant Kingdom. Here we describe recent progress in methods for pathway discovery, DNA synthesis and assembly, and expression of engineered pathways in heterologous hosts. We also highlight the importance of standardization and the challenges associated with dataset integration in the drive to build a systematic framework for effective harnessing of plant metabolic diversity.

Citations

Jan 10, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuki Saito
Oct 21, 2018·The Plant Journal : for Cell and Molecular Biology·Yi Shang, Sanwen Huang
Mar 23, 2019·The Plant Journal : for Cell and Molecular Biology·Daniela Eisenschmidt-BönnWolfgang Brandt
Apr 23, 2020·Frontiers in Pharmacology·Emmanuelle LautiéJean A Boutin
Apr 18, 2018·Plant Cell Reports·Cynthia K Holland, Joseph M Jez
Jul 25, 2019·Nature Plants·Tomáš PluskalJing-Ke Weng
Jun 27, 2019·Cold Spring Harbor Perspectives in Biology·Thomas Louveau, Anne Osbourn
Sep 29, 2019·The Journal of Biological Chemistry·Hiroshi A Maeda
Sep 6, 2018·Annual Review of Genetics·Hans-Wilhelm NützmannAnne Osbourn
May 23, 2018·Plant Cell Reports·James Reed, Anne Osbourn
Feb 23, 2021·Frontiers in Genetics·Susana González-MoralesAdalberto Benavides-Mendoza
Jun 29, 2021·Frontiers in Plant Science·Ramona GrütznerSylvestre Marillonnet
Nov 13, 2019·ACS Synthetic Biology·Michael Patrick Torrens-SpenceJing-Ke Weng
Sep 3, 2020·ACS Central Science·Amy Calgaro-KozinaPatrick M Shih
Nov 23, 2021·The Plant Journal : for Cell and Molecular Biology·Samuel Lopez-NievesHiroshi A Maeda

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